| 中文名称: | Epacadostat | ||||
|---|---|---|---|---|---|
| 英文名称: | Epacadostat | ||||
| 别名: | 艾卡哚司他 INCB24360;(Z)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-4-((2-(sulfamoylamino)ethyl)amino)-1,2,5-oxadiazole-3-carboximidamide | ||||
| CAS No: | 1204669-37-3 | 分子式: | C11H13BrFN7O4S | 分子量: | 438.23 |
| CAS No: | 1204669-37-3 | ||||
| 分子式: | C11H13BrFN7O4S | ||||
| 分子量: | 438.23 | ||||
一种口服的IDO1抑制剂，具有潜在的免疫调节和抗肿瘤活性。
Epacadostat is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. INCB024360 targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs)。
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
