| 中文名称: | Endoxifen E-isomer hydrochloride | ||||
|---|---|---|---|---|---|
| 英文名称: | Endoxifen E-isomer hydrochloride | ||||
| 别名: | Endoxifen E-isomer hydrochloride 4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol hydrochloride | ||||
| CAS No: | 1197194-61-8 | 分子式: | C25H28ClNO2 | 分子量: | 409.95 |
| CAS No: | 1197194-61-8 | ||||
| 分子式: | C25H28ClNO2 | ||||
| 分子量: | 409.95 | ||||
一种他莫西芬（Tamoxifen）代谢产物，一种有效的选择性雌激素反应调节剂（SERM）。
Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). Target: Estrogen Receptor/ERR Endoxifen is considered a prodrug, since it has a much higher potency for the estrogen receptor than its parent drug. Endoxifen inhibits the hERG channel protein trafficking to the plasma membrane in a concentration-dependent manner with Endoxifen being more potent than Tamoxifen. Endoxifen is also shown to be a more potent inhibitor of estrogen target genes when ERβ is expressed. Additionally, low concentrations of Endoxifen observed in Tamoxifen treated patients with deficient CYP2D6 activity (20 to 40 nM) markedly inhibit estrogen-induced cell proliferation rates in the presence of ERβ, whereas much higher Endoxifen concentrations are needed when ERβ is absent.
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
