中文名称: | 多佐胺 | ||||
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英文名称: | Dorzolamide | ||||
别名: | (2R,4R)-2-乙基氨基-4-甲基-5,5-二氧代-5,7-二硫杂双环[4.3.0]壬-8,10-二烯-8-磺酰胺 L671152;MK507;(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxid | ||||
CAS No: | 120279-96-1 | 分子式: | C10H16N2O4S3 | 分子量: | 324.44 |
CAS No: | 120279-96-1 | ||||
分子式: | C10H16N2O4S3 | ||||
分子量: | 324.44 |
基本信息
产品编号: |
D70149 |
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产品名称: |
Dorzolamide |
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CAS: |
120279-96-1 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
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分子量 |
324.44 |
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化学名: |
(4S,6S)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxid |
生物活性
产品描述 |
一种有效的碳酸酐酶carbonic anhydraseII的抑制剂 |
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体外研究 |
Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dosedependent manner with an 50% inhibitory concentration IC50 of 2.4μM (95% confidence interval: 0.5-10.85μM |
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体内研究 |
Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively) |
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Animal Model: |
Female Swiss albino mice (EAC solid tumor) |
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Dosage: |
3, 10, or 30 mg/kg/day (synergized mitomycin C). |
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Administration: |
IP, daily for 3 weeks. |
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Result: |
Upregulated TXNIP and p53 while downregulated bcl-2. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )