| 中文名称: | Duloxetine hydrochloride 促销 | ||||
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| 英文名称: | Duloxetine hydrochloride | ||||
| 别名: | 盐酸度洛西汀 (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride | ||||
| CAS No: | 136434-34-9 | 分子式: | C18H19NOs.HCl | 分子量: | 333.88 |
| CAS No: | 136434-34-9 | ||||
| 分子式: | C18H19NOs.HCl | ||||
| 分子量: | 333.88 | ||||
基本信息
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产品编号： |
D20014 |
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产品名称： |
Duloxetine hydrochloride |
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CAS: |
136434-34-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
两年 |
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分子量 |
333.88 |
-20℃ |
1个月 |
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化学名： |
(S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
67 mg/mL (200.67mM) |
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Ethanol |
6 mg/mL (17.97mM) |
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Water |
Insoluble |
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体内(现配现用): |
1.请依序添加每种溶剂： PBS Solubility: 140 mg/mL (419.31mM); Clear solution; Need ultrasonic |
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2.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80 →45% saline Solubility: ≥ 2.5 mg/mL (7.49mM); Clear solution |
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此⽅案可获得 ≥ 2.5 mg/mL (7.49mM，饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50μL Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。 |
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3.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (7.49mM); Clear solution |
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此⽅案可获得 ≥ 2.5 mg/mL (7.49mM，饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均 匀。 |
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4.请依序添加每种溶剂：10% DMSO→90% corn oil Solubility: ≥ 2.5 mg/mL (7.49mM); Clear solution |
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此⽅案可获得 ≥ 2.5 mg/mL (7.49mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。 以 1 mL ⼯作液为例，取 100μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900μL ⽟⽶油中，混合均匀。 |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.9951mL |
14.9754mL |
29.9509mL |
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5mM |
0.5990mL |
2.9951mL |
5.9902mL |
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10mM |
0.2995mL |
1.4975mL |
2.9951mL |
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50mM |
0.0599mL |
0.2995mL |
0.5990mL |
生物活性
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产品描述 |
5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI)，Ki 为 4.6nM，可作用于广泛性焦虑症。 |
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靶点 |
5-HT |
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体外研究 |
Duloxetine ((S)-Duloxetine hydrochloride) (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela, Dulane) is a serotonin-norepinephrine reuptake inhibitor(SNRI) manufactured and marketed by Eli Lilly. It is prescribed for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine also has approval for use in osteoarthiritis and musculoskeletal pain. Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery. It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy, and it is used to control the symptoms of fibromyalgia. The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy,fibromyalgia, and chronic musculoskeletal pain associated with osteoarthritis and chronic lower back pain. It is being studied for various other indications. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
