中文名称: DuP 734
英文名称: DuP 734
CAS No: 135135-87-4
分子式: C17H23BrFNO
分子量: 356.27
D11523 DuP 734 ≥98% (psaitong)
包装规格:
5mg 10mg 50mg 100mg in glass bottle
溶解性:
溶于DMSO(250mg/mL超声)
产品描述:

基本信息

产品编号:

D11523 

产品名称:

DuP 734

CAS:

135135-87-4

 

储存条件

粉末

-20℃

四年

分子式:

C17H23BrFNO

溶于液体

-80℃(存于氮气,防潮)

6个月

分子量:

356.27

-20℃(存于氮气,防潮)

1个月

化学名: 

1-(Cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'-oxoethyl)piperidine

Solubility (25°C):

 

体外:

 

DMSO

 

Ethanol

 

Water

 

体内(现配现用):

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

2.8069mL

14.0343mL

28.0686mL

5mM

0.5614mL

2.8069mL

5.6137mL

10mM

0.2807mL

1.4034mL

2.8069mL

 

生物活性

产品描述

一种 sigma 受体拮抗剂,DuP 734 是一种有效的选择性 sigma 和 5-HT2 受体配体,对 D2 受体的亲和力弱。DuP 734 具有抗精神病活性,而没有抗精神病剂常见的副作用。

靶点

Sigma receptor;5-HT2 receptor;D2 receptor

体内研究

DuP 734 potently blocks mescaline-induced scratching (ED50=0.35mg/kg,p.o.) and aggressive activity (ED50=1.9mg/kg,p.o.) and is relatively much weaker as an apomorphine antagonist (ED50=12mg/kg,p.o.).Administration of DuP 734 potently antagonizes the binding of [3H]DuP 734 and [3H](+)-SKF 10,047 to brain sigma receptors in vivo with ID50 values of 0.02 and 0.07mg/kg (0.07 and 0.25μmol/kg),respectively.Following intravenous dosing,the disposition of DuP 734 in mice,rats,beagle dogs and cynomolgus monkeys is characterized by high total body systemic plasma clearance (46 to 87mL/min/kg) and large steady-state volume of distribution (3.6 to 6.8L/kg).The terminal elimination half-life ranged from 50 to 83 min.The gastrointestinal absorption from an aqueous solution is very rapid in mice and rats with peak DuP 734 plasma concentrations attain within 5 and 20 min following administration,respectively.The peak plasma concentrations in dogs and monkeys are attained within 45 and 130 min,respectively.The absolute bioavailability in mice ranges from 29 to 46% at doses of 3.1 to 30.1mg/kg.The bioavailability increases from 4 to 10% and from 14 to 72% when doses are increased from 12.5 to 50mg/kg and 1 to 3mg/kg of DuP 734 in rats and dogs, respectively.The bioavailability in monkeys is 30.5% at 9.3mg/kg DuP 734 dose.The dose dependent pharmacokinetics of DuP 734 is observed within narrow dose ranges in all animal species investigated.

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

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用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

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连续稀释计算器方程

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  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):