| 中文名称: | 二甲啡烷磷酸盐 | ||||
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| 英文名称: | Dimemorfan phosphate | ||||
| 别名: | 磷酸二甲啡烷 3,17-Dimethyl-9-alpha,13-alpha,14-alpha-morphinan phosphate | ||||
| CAS No: | 36304-84-4 | 分子式: | C18H28NO4P | 分子量: | 353.39 |
| CAS No: | 36304-84-4 | ||||
| 分子式: | C18H28NO4P | ||||
| 分子量: | 353.39 | ||||
| EINEC: | 252-958-6 | ||||
| EINEC: | 252-958-6 | ||||
基本信息
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产品编号： |
D11522 |
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产品名称： |
Dimemorfan phosphate |
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CAS: |
36304-84-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃(密封储存) |
6个月 |
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分子量： |
353.39 |
-20℃(密封储存) |
1个月 |
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化学名： |
3,17-Dimethyl-9-alpha,13-alpha,14-alpha-morphinan phosphate |
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Solubility (25°C)： |
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体外:
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DMSO |
Insoluble |
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Ethanol |
'-1mg/mL |
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Water |
30mg/mL (84.89mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.8297mL |
14.1487mL |
28.2973mL |
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5mM |
0.5659mL |
2.8297mL |
5.6595mL |
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10mM |
0.2830mL |
1.4149mL |
2.8297mL |
生物活性
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产品描述 |
一种sigma 1 receptor 的有效激动剂，能够有效止咳。 |
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靶点 |
σ1 receptor |
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150nM(Ki) |
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体外研究 |
Dimemorfan (5-20μM) inhibits both fMLP-and PMA-induced ROS production in a concentration-dependent manner and is relatively more potent in inhibiting fMLP-induced ROS production with an IC50 value of 7.0μM.Dimemorfan (10-50μM) does not display significant activity in scavenging free radicals by xanthine/xanthine oxidase system.Dimemorfan significantly suppressed Mac-1 upregulation both in PMA- and fMLP-activated groups.Dimemorfan (10-20μM) significantly suppresses LPS-induced ROS and NO production,and suppresses LPS-induced iNOS protein expression,and both the percentage of the positively stained population and the MCF intensities of MCP-1 and TNF-α in BV2 cytosol.Dimemorfan (20μM) significantly blocks the degradation of cytosolic Iκ-Bα and nuclear translocation of NF-κB p65,as well as the transcriptional activity of NFκB. |
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体内研究 |
Dimemorfan (6.25 or 12.5mg/kg,s.c.) significantly attenuates the BAY k-8644-induced convulsive behaviors,in a dose related manner (6.25mg/kg dimemorfan+BAY k-8644 or 12.5mg/kg dimemorfan+BAY k-8644 versus Saline+BAY k-8644,P<0.05 and P<0.01,respectively).Dimemorfan significantly attenuates BAY k-8644-induced increases in the c-fos and c-jun protein expression in a dose-dependent manner.Dimemorfan does not significantly affect locomotor activity or produce significant circling behavior in any locomotor pattern in mice.Dimemorfan (1 and 5mg/kg,i.p.) surpresses the incarease of the plasma levels of TNF-α in mice.The infiltration of neutrophils into lung and liver as well as the production of oxidative stress (EB staining) in these tissues induced by LPS is markedly inhibited by the treatment with dimemorfan. |
推荐实验方法(仅供参考)
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动物实验: |
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C57BL/6 mice receive each morphinan (dextromethorphan,dextrorphan or dimemorfan) compound (20 or 40mg/kg,i.p.per day) or PCP (2.5 or 5mg/kg,i.p.per day) once a day for 7 days.Ten minutes after the last treatment with each drug,locomotor activity is measured for 30 min using an automated video-tracking system.Eight test boxes (40 cm×40 cm×30 cm high) are operated simultaneously by an IBM computer.Animals are studied individually during locomotion in each test box,where they are adapted for 10 min before starting the experiment.A printout for each session showed the pattern of the ambulatory movements of the test box.The distance traveled in cm by the animals in horizontal locomotor activity is analyzed.Data are collected and analyzed between 09:00 and 17:00h. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
