N-去甲基氯氮平 - CAS:6104-71-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	N-去甲基氯氮平
英文名称:	N-Desmethylclozapine
别名:	N-去甲基氯氮平 Norclozapine; Desmethylclozapine; Normethylclozapine
CAS No:	6104-71-8	分子式:	C₁₇H₁₇ClN₄	分子量:	312.8
CAS No:	6104-71-8
分子式:	C₁₇H₁₇ClN₄
分子量:	312.8

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D11122 N-去甲基氯氮平 ≥98% (psaitong)

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包装规格：

10mg 50mg 250mg in glass bottle

溶解性：

溶于(DMS:≥50mg/mL)

产品描述：

基本信息

产品编号：	D11122
产品名称：	N-Desmethylclozapine
CAS:	6104-71-8	储存条件	粉末	-20℃	四年

分子式：	C17H17ClN4		溶于液体	-80℃	6个月
分子量：	312.80			-20℃	1个月
化学名：	N-Desmethylclozapine solution,1.0 mg/mL in methanol,ampule of 1mL,certified reference material
Solubility (25°C)：
体外:	DMSO
	Ethanol
	Water
体内(现配现用):
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	3.1969mL	15.9847mL	31.9693mL
5mM	0.6394mL	3.1969mL	6.3939mL
10mM	0.3197mL	1.5985mL	3.1969mL

生物活性

产品描述	一种非典型抗精神病药 Clozapine 的主要活性代谢产物。N-Desmethylclozapine 是一种有效的、变构的部分 M1 受体激动剂 (EC50=115nM)能通过 M1 受体激活增强海马 N-methyl-d-aspartate (NMDA) 受体电流。N-Desmethylclozapine 也是 δ-opioid 激动剂。
靶点	EC50:115nM (M1 receptors)δ-opioid
体外研究	The brain penetrant metabolite N-desmethylclozapine preferentially bound to M1 muscarinic receptors with an IC50 of 55nM and was a more potent partial agonist (EC50,115nM and 50% of acetylcholine response) at this receptor than clozapine.N-desmethylclozapine exhibits slight agonistic effects on the M1 mAChR,and agonistic properties at the 5-HT1A receptor in the cerebral cortex and hippocampus.This compound also behaves as an agonist at the δ-opioid receptor in the cerebral cortex and striatum.N-desmethylclozapine (3μM) greatly decreases the outward current in excitatory neurons,but not in inhibitory neurons.In excitatory neurons,N-desmethylclozapine alone is more effective than either clozapine alone or the combination of clozapine and N-desmethylclozapine.The effect of N-desmethylclozapine in excitatory neurons is significantly suppressed by 0.1μM pirenzepine and 1μM atropine.N-desmethylclozapine,but not clozapine,suppressed K+channels via M1 receptors in excitatory cells.N-desmethylclozapine leads to a decrease in TxB2 levels under unstimulated conditions as well as under TSST-1 stimulation.Clozapine,N-desmethylclozapine and CPZ possibly act on neurotransmitter systems via modulation of TxA2 or TxB2 production.The IC50s of N-desmethylclozapine,fluoxetine hydrochloride,and salmeterol xinafoate in Huh-7 cells infected with DENV-2 are 1μM,0.38μM,and 0.67μM,respectively.The levels of NS3 are reduced in cells treated with all three inhibitors compared to DMSO treatment,suggesting that the inhibitors act at a stage prior to viral protein translation.N-Desmethylclozapinetreated cells show a >75% reduction in negative-strand RNA levels.
体内研究	N-desmethylclozapine in rat and human at M2 and M4 mAChRs underlying presynaptic modulation of GABA and glutamate release,respectively.In particular,N-desmethylclozapine maybe a M2 mAChR antagonist in the rat but has no activity at this receptor in human neocortex.However,N-desmethylclozapine has an agonistic effect at M4 mAChR in the human but no such effect in the rat neocortex.

保存条件：

-20℃

UN码：

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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果