| 中文名称: | Darodipine | ||||
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| 英文名称: | Darodipine | ||||
| 别名: | CP-060 CP-060 | ||||
| CAS No: | 72803-02-2 | 分子式: | C19H21N3O5 | 分子量: | 371.39 |
| CAS No: | 72803-02-2 | ||||
| 分子式: | C19H21N3O5 | ||||
| 分子量: | 371.39 | ||||
基本信息
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产品编号： |
D11018 |
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产品名称： |
Darodipine |
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CAS: |
72803-02-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
四年 |
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分子量： |
371.39 |
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化学名： |
3,5-Pyridinedicarboxylic acid,4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-,diethyl ester |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种有效地钙离子通道(calciumchanel)拮抗剂。 |
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靶点 |
Calcium Channel |
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体内研究 |
Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats.The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine.Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders.A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex. |
推荐实验方法(仅供参考)
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动物实验: |
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Rats:Male Wistar rats are used.Twelve-month-old rats are left untreated and used as adult reference animals.Twenty-onemonth-old rats are allotted randomly to two groups of 8 animals each. Rats of the first group receive an oral daily dose of 5mg/kg of darodipine in drinking water.The animals of the second group are left untreated and served as a control group.Rats of these two groups are allowed to survive for 6 months,until 27 months of age (old rats).Darodipine-treated rats have water consumption determined every second day and body weight determined weekly. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
