| 中文名称: | (+)-Dihydrexidine hydrochloride | ||||
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| 英文名称: | (+)-Dihydrexidine hydrochloride | ||||
| 别名: | (+)-DAR-0100 (hydrochloride) | ||||
| CAS No: | 158704-02-0 | 分子式: | C17H17NO2.HCl | 分子量: | 303.78 |
| CAS No: | 158704-02-0 | ||||
| 分子式: | C17H17NO2.HCl | ||||
| 分子量: | 303.78 | ||||
基本信息
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产品编号： |
D10884 |
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产品名称： |
(+)-Dihydrexidine hydrochloride |
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CAS: |
158704-02-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
二年 |
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分子量： |
303.78 |
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化学名： |
Benzo[a]phenanthridine-10,11-diol,5,6,6a,7,8,12b-hexahydro-,hydrochloride (1:1),(6aR,12bS)-rel- |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种多巴胺 D1 受体激动剂，EC50 为 72±21nM。 |
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靶点 |
EC50:72±21nM (Dopamine D1 receptor) |
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体外研究 |
(+)-Dihydrexidine hydrochloride (DHX) is a high-potency,bioavailable D1 dopamine receptor agonist.(+)-Dihydrexidine is screened for activity against 40 other binding sites,and is inactive (IC50 greater than 10 microM) against all except D2 dopamine receptors (IC50=130nM) and alpha 2 adrenoreceptors (IC50=230nM).Dihydrexidine competes stereoselectively and potently for D1 binding sites in rat striatal membranes labeled with [3H]SCH23390 with an IC50 of about 10nM compared to about 30nM for the prototypical D1 agonist SKF38393. |
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体内研究 |
To examine the functional state of striatal neurons in response to D1 receptor activation,AC5+/+and AC5-/-mice are injected with the D1 agonist (+)-Dihydrexidine (30mg/kg,i.p.) and obtained the dorso-lateral striatum and NAc,separately,45 min later for RT-PCR analysis.These experiments reveal that (+)-Dihydrexidine -triggered induction of the immediate early genes,c-fos,egr-1,and junB,in the NAc is markedly enhanced in AC5-/-mice compared with that in AC5+/+mice,while the induction in the dorso-lateral striatum is suppressed in AC5-/-mice. |
推荐实验方法(仅供参考)
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动物实验: |
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Mice AC5-/-mice are backcrossed to the C57BL/6J strain for 9 or 10 generations to obtain heterozygote N9 or N10 mice.Mice are treated with (+)-Dihydrexidine (30mg/kg,i.p.). |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
