Datelliptium chloride - CAS:105118-14-7 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Datelliptium chloride
英文名称:	Datelliptium chloride
CAS No:	105118-14-7	分子式:	C₂₃H₂₈ClN₃O	分子量:	397.94
CAS No:	105118-14-7
分子式:	C₂₃H₂₈ClN₃O
分子量:	397.94

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

D10815 Datelliptium chloride ≥98% (psaitong)

相关产品

包装规格：

25mg in glass bottle

溶解性：

溶于水（41.67mg/mL 超声），溶于DMSO（5mg/mL 超声）

产品描述：

基本信息

产品编号：D10815
产品名称：Datelliptium chloride
CAS:	105118-14-7	储存条件	粉末	-20℃	四年

分子式：	C23H28ClN3O		溶于液体	-80℃	六个月
分子量	397.94			-20℃	一个月
化学名：	2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium chloride
Solubility (25°C)	体外	DMSO	5mg/mL (12.56mM; Need ultrasonic)
		Ethanol
		Water	40mg/mL (100.52mM; Need ultrasonic
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.5129mL	12.5647mL	25.1294mL
5mM	0.5026mL	2.5129mL	5.0259mL
10mM	0.2513mL	1.2565mL	2.5129mL

生物活性

产品描述	一种源于 ellipticine 的 DNA 嵌合剂，具有抗肿瘤活性。
靶点/IC₅₀	DNA/RNA Synthesis
体外研究	Datelliptium (100μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate.
体内研究	Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170mg/kg TD, and weight loss of 10%, T/C of 0%.

推荐实验方法(仅供参考)

细胞实验：

Cell Assay

Cytotoxicity is estimated after short-term exposure (2 hr) to datelliptium using suspended and cultured rat hepatocytes. When cytotoxicity is evaluated after longer-term exposure, using human and rat monolayers and hepatoma cell lines, the compound is added 1 hr after cell plating and incubated for 23 hr. The loss of intracellular LDH and the MTT test are the endpoints evaluated in cultured cells. The intracellular LDH is measured in the microwell culture plates by a colorimetric method. The MTT test, reduction of the tetrazolium salt MTT to formazan by mitochondrial succinate dehydrogenase, is performed as described. Cytotoxicity in the hepatocyte suspension is evaluated by LDH leakage to the medium after a 2-hr treatment with the drug.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果