| 中文名称: | 决奈达隆 | ||||
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| 英文名称: | Dronedarone | ||||
| 别名: | 决奈达龙 SR 33589 | ||||
| CAS No: | 141626-36-0 | 分子式: | C31H44N2O5S | 分子量: | 556.76 |
| CAS No: | 141626-36-0 | ||||
| 分子式: | C31H44N2O5S | ||||
| 分子量: | 556.76 | ||||
| MDL: | MFCD00910331 | ||||
基本信息
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产品编号： |
D10794 |
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产品名称： |
Dronedarone |
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CAS: |
141626-36-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
556.76 |
-20℃ |
1个月 |
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化学名： |
N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.7961mL |
8.9805mL |
17.9611mL |
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5mM |
0.3592mL |
1.7961mL |
3.5922mL |
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10mM |
0.1796mL |
0.8981mL |
1.7961mL |
生物活性
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产品描述 |
胺碘酮的衍生物，是一种用于研究心房颤动 (AF) 的 class III 抗心律失常的试剂 (antiarrhythmic agent)。 |
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靶点 |
mAChR |
Sodium Channel |
Calcium Channel |
Adrenergic Receptor |
Cytochrome P450 |
Autophagy |
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体外研究 |
In patch clamp experiments using human atrial myocytes,Dronedarone produces potent blockade of peak sodium current,resulting in a 97% block at 3μM.In guinea pig ventricular myocytes,Dronedarone inhibits the rapidly activating delayed-rectifier potassium current (IC50<3μM),the slowly activating delayed-rectifier potassium current (IC50=10μM),the inward rectifier potassium current (IC50>30μM),and L-type calcium current (IC50=0.18μM).Dronedarone exhibits strong inhibitory effects on the acetylcholine-activated potassium current (IK-Ach) in rabbit inoatrial nodal cells (IC50=63nM) and guinea pig atrial cells (IC50=10nM).Blockade of IK-Ach by dronedarone is 100 times more potent than that of amiodarone.Dronedarone exerts its antiadrenergic effects by noncompetitive binding to β-adrenergic receptors (IC50=1.8μM) and inhibition of agonist-induced increases in adenylate cyclase activity.Dronedarone (0.01-1μM) induces a concentration-dependent reduction of coronary perfusion pressure in isolated guinea pig hearts, effects that are independent of the nitric oxide synthase pathway and possibly related to its calcium current blockade. |
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体内研究 |
Dronedarone (intraperitoneal injection;25-100mg/kg) exhibits anticonvulsant effects in a dose-dependent manner and increases the threshold for electroconvulsions in mice. |
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Animal Model: |
Tonic-clonic seizures in male albino Swiss outbred mice |
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Dosage: |
25mg/kg;50mg/kg;75mg/kg;100mg/kg |
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Administration: |
Intraperitoneal injection |
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Result: |
Showed significant anticonvulsant effects. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
