中文名称: | 甲磺酸多沙唑嗪 | ||||
---|---|---|---|---|---|
英文名称: | Doxazosin mesylate | ||||
别名: | 甲磺酸多沙唑嗪 UK 33274 mesylate | ||||
CAS No: | 77883-43-3 | 分子式: | C23H25N5O5.CH3SO3H | 分子量: | 547.58 |
CAS No: | 77883-43-3 | ||||
分子式: | C23H25N5O5.CH3SO3H | ||||
分子量: | 547.58 | ||||
MDL: | MFCD00216023 | EINEC: | 7082 | ||
EINEC: | 7082 |
基本信息
产品编号: |
D10793 |
||||
产品名称: |
Doxazosin mesylate |
||||
CAS: |
77883-43-3 |
储存条件 |
粉末 |
2-8℃ |
四年 |
|
|
||||
分子式: |
溶于液体 |
-80℃ |
6个月 |
||
分子量: |
547.58 |
-20℃ |
1个月 |
||
化学名: |
|||||
Solubility (25°C): |
|||||
体外:
|
DMSO |
27mg/mL (49.3mM) |
|||
Ethanol |
Insoluble |
||||
Water |
Insoluble |
||||
体内(现配现用): |
|
||||
<1mg/ml表示微溶或不溶。 |
|||||
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
|||||
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.8262mL |
9.1311mL |
18.2622mL |
5mM |
0.3652mL |
1.8262mL |
3.6524mL |
10mM |
0.1826mL |
0.9131mL |
1.8262mL |
生物活性
产品描述 |
甲磺酸盐能选择性拮抗突触后的α1肾上腺素受体。 |
靶点 |
α1-adrenergic receptor |
体外研究 |
UK 33274 mesylate is the mesylate salt form of doxazosin,which is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms.doxazosin may have a direct inhibitory effect on cholesterol synthesis independent of the LDL receptor.The inhibition of cholesterol synthesis by doxazosin may cause cells to compensate by upregulating the LDL receptor,thereby increasing the importation of lipoprotein cholesterol and reducing LDL cholesterol in the medium.Doxazosin monotherapy was effective in eight of 12 patients (66.7%),and combined therapy with a beta-blocker was effective in 11 o 12 patients (91.7%).The mean pulse rate remained constant throughout therapy.Adverse reactions were minor and transient and occurred in only three patients.Urinary and plasma catecholamine levels tended to decrease or remained unchanged during doxazosin therapy. |
体内研究 |
Doxazosin也降低平均动脉压为18%,而不会影响所有仓鼠的心脏速率。Doxazosin显著降低Beta TGF-β1感染小鼠前列腺重建(MPR)的湿重。 |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )