| 中文名称: | DuP-697 | ||||
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| 英文名称: | DuP-697 | ||||
| 别名: | 5-?Bromo-?2-?(4-?fluorophenyl)?-?3-?[4-?(methylsulfonyl)?phenyl]?-thiophene | ||||
| CAS No: | 88149-94-4 | 分子式: | C17H12BrFO2S2 | 分子量: | 411.31 |
| CAS No: | 88149-94-4 | ||||
| 分子式: | C17H12BrFO2S2 | ||||
| 分子量: | 411.31 | ||||
基本信息
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产品编号： |
D10776 |
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产品名称： |
DuP-697 |
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CAS: |
88149-94-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
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分子量 |
411.31 |
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化学名： |
5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl)thiophene |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种有效，不可逆，选择性和口服活性的COX-2抑制剂(对于人COX-2和COX-1，IC50分别为10nM和800nM)。DuP-697对HT29大肠癌细胞具有抗增殖作用(IC50为42.8nM)，抗血管生成和促凋亡作用。 |
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靶点 |
hCOX-2 10nM(IC50) |
hCOX-1 800nM(IC50) |
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体外研究 |
DuP-697 (0-100nM; 24 hours; HT29 cells) treatment shows antiproliferative with an IC50 value of 42.8nM DuP-697 (25-100nM; 72 hours; HT29 cells) treatment causes concentration dependent apoptosis in HT29 cells. The percentage of UR (apoptosis portion) area increases gradually according to the concentration of DuP-697 from 7% in control group to 52% in 100nM DuP-697 DuP-697 in 100, 10 and 1nM concentrations cause antiangiogenic effect. Antiangiogenic scores of DuP-697 are 1.2, 0.8 and 0.5, respectively Cell Proliferation Assay |
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Cell Line: |
HT29 cells |
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Concentration: |
0nM,12.5nM,25nM,50nM,100nM |
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Incubation Time: |
24 hours |
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Result: |
Exhibited decreasing CI values in a concentration dependent manner. Showed statistically significant cytotoxic effect. |
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Apoptosis Analysis |
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Cell Line: |
HT29 cells |
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Concentration: |
25nM,50nM,100nM |
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Incubation Time: |
72 hours |
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Result: |
Caused concentration dependent apoptosis in HT29 cells. |
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体内研究 |
DuP-697 is a potent inhibitor of paw swelling in nonestablished and established adjuvant arthritis in rats (ED50 = 0.03 and 0.18mg/kg/day, respectively). DuP-697 has no effect on phenylquinone writhing in rats (ED50 greater than 100mg/kg), but is analgetic against inflammation-related pain in the Randall-Selitto assay (ED50 = 3.5mg/kg) and is a very potent antipyretic agent (ED50 = 0.05mg/kg). DuP-697 (5mg/kg i.v.) does not alter renal blood flow or the renal vascular response to angiotensin II in furosemide-pretreated, volume-depleted rats DuP-697 is a moderate inhibitor of bull seminal vesicle prostaglandin (PG) synthesis (IC50 of 24μM) and a potent inhibitor of rat brain PG synthesis (IC50 of 4.5μM) but was ineffective against rat kidney PG synthesis (IC50 of 75μM) |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
