| 中文名称: | DC_AC50 | ||||
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| 英文名称: | DC_AC50 | ||||
| 别名: | 3-amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide 3-Amino-N-(2-bromo-4,6-difluorophenyl)-6,7-dihydro-5H-cyclopenta[b]thieno[3,2-e]pyridine-2-carboxamide | ||||
| CAS No: | 497061-48-0 | 分子式: | C17H12BrF2N3Os | 分子量: | 424.26 |
| CAS No: | 497061-48-0 | ||||
| 分子式: | C17H12BrF2N3Os | ||||
| 分子量: | 424.26 | ||||
基本信息
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产品编号：D10775 |
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产品名称：DC_AC50 |
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CAS: |
497061-48-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
424.26 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.3570mL |
11.7852mL |
23.5705mL |
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5mM |
0.4714mL |
2.3570mL |
4.7141mL |
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10mM |
0.2357mL |
1.1785mL |
2.3570mL |
生物活性
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产品描述 |
一种 Atox1 和 CCS (铜伴侣蛋白) 的双抑制剂。抑制细胞内铜伴侣可作为减少/防止获得性化疗耐药的一种策略。 |
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靶点/IC50 |
Apoptosis |
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体外研究 |
DC_AC50 exhibits IC50 values of 9.88μM, 12.57μM, 5.96μM and 6.68μM in Canine Abrams,Canine D1, human HOS and human MG63) cells, respectively.DC_AC50 (0-10μM)-treated cells are significantly less mitotically active, as demonstrated by decreased expression of phospho-histone H3 and cell cycle analysis.DC_AC50 (10μM) potentiates carboplatin-induced apoptosis in OSA cells and decreasesclonogenic survival.DC_AC50 induces cell cycle arrest at both the 3 and 10μM doses and DC_AC50 induces increase S phase cells doseindependently.DC_AC50 (3μM) inhibits the migration and of canine and human OSA cells.DC_AC50 (2.5-10μM) is highly efficient at inhibiting cancer cell proliferation (human lung cancer H1299 cells, leukaemia cancer K562 cells,breast cancer MDA-MB-231 cells and head and neck cancer 212LN cells) in a dose-dependent manner.DC_AC50 fails to exhibit any notable inhibition of the cell proliferation of human normal epithelial lung BEAS-2B cells or breast MCF-10A cells as control cells. |
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Cell Line: |
Canine OSA (Abrams, D1 and human OSA (HOS, MG63) cells. |
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Concentration: |
0-10μM |
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Incubation Time: |
72h. |
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Result: |
Dose-dependently decreased viability of OSA cells. |
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Apoptosis Analysis |
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Cell Line: |
Abrams and HOS cells. |
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Concentration: |
1,3 and 10μM (10μM Carboplatin). |
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Incubation Time: |
24h. |
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Result: |
Potentiated carboplatin-induced apoptosis. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
