Deferasirox - CAS:201530-41-8 - CAS号查询_生物试剂_化学试剂_分析试剂

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D10600 Deferasirox ≥98% (psaitong)

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包装规格：

1g 5g 25g 100g in glass bottle

溶解性：

溶于DMSO（≥ 100 mg/mL)

产品描述：

基本信息

产品编号：D10600
产品名称：Deferasirox
CAS:	201530-41-8	储存条件	粉末	-20℃	四年

分子式：	C21H15N3O4		溶于液体	-80℃	两年
分子量	373.36			-20℃	一个月
化学名：	4-(3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid
Solubility (25°C)	体外	DMSO	75mg/mL (200.87mM)
		Ethanol	2mg/mL (5.35mM)
		Water	Insoluble
	体内（现配现用）	5% DMSO+40% PEG 300+5%Tween 80 +50 % H2O	3.7mg/mL
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

生物活性

产品描述	一种具有口活性的，可用于铁离子过量的螯合剂。
靶点/IC₅₀	Bacterial	Ferroptosis
体外研究	In LX-2 cells treated with 50 μM deferasirox for 12 h, α1(I)procollagen expression is decreased by 25%, with maximal reductions (10-fold) seen following 24-120 h of treatment. Similarly, α-smooth muscle actin (αSMA) expression is significantly lower. Deferasirox had anti-proliferative effects on HL-60 or KG-1 myeloid leukemia cell lines at a concentration as low as 5 μM . The cytotoxicity is both dose and time dependent. The viability of both EL4 cells and L1210 cells incubated with deferasirox decrease in a concentration-dependent manner.
体内研究	The tumor is significantly smaller in the SIO mice treated with deferasirox compared with control. Mice treated with DFX showed longer survival than the other groups. Deferasirox has a survival benefit for SIO leukemia murine model in terms of iron chelation and antileukemic therapy.
特征

推荐实验方法(仅供参考)

细胞实验:
Cell Assay	Deferasirox is dissolved in DMSO. HL-60 or KG-1 cells are treated with 0, 5, 10, 50μM of deferasirox for 24 or 48h, and proliferation is determined by an MTT assay.

动物实验:
Animal Administration	Mice: Murine leukemia cells are injected subcutaneously into the right flank of mice. Deferasirox is dissolved in distilled water and orally administered at 20 mg/kg until the cumulative dose reaches 300 mg/kg. The mice are observed and weighed daily.

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )