基本信息
产品编号: |
D10120 |
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产品名称: |
3,4-Dihydroxybenzaldehyde |
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CAS: |
139-85-5 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式: |
溶于液体 |
-80℃ |
两年 |
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分子量 |
138.12 |
-20℃ |
一个月 |
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化学名: |
4-(Hydroxymethylene)-2-hydroxy-2,5-cyclohexadien-1-one |
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Solubility (25°C): |
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体外:
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DMSO |
27mg/mL (195.48mM) |
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Ethanol |
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Water |
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体内(现配现用): |
1.请依序添加每种溶剂:10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 2.5mg/mL (18.10mM); Clear solution |
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此⽅案可获得 ≥ 2.5mg/mL (18.10mM,饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例,取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中,混合均匀;向上述体系中加⼊ 50μL Tween-80,混合均匀;然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。 |
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2.请依序添加每种溶剂:10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5mg/mL (18.10mM); Clear solution |
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此⽅案可获得 ≥ 2.5mg/mL (18.10mM,饱和度未知) 的澄清溶液。以 1mL ⼯作液为例,取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中,混合均匀。 |
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3.请依序添加每种溶剂:10% DMSO→90% corn oil Solubility: ≥ 2.5mg/mL (18.10mM); Clear solution |
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此⽅案可获得 ≥ 2.5mg/mL (18.10mM,饱和度未知) 的澄清溶液,此⽅案不适⽤于实验周期在半个⽉以上的实验。 以 1mL ⼯作液为例,取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL ⽟⽶油中,混合均匀。 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
7.2401mL |
36.2004mL |
72.4008mL |
5mM |
1.4480mL |
7.2401mL |
14.4802mL |
10mM |
0.7240mL |
3.6200mL |
7.2401mL |
50mM |
0.1448mL |
0.7240mL |
1.4480mL |
生物活性
产品描述 |
Protocatechualdehyde (Catechaldehyde) 是从 Salviae Miltiorrhizae 中分离出来的⼀种天然多酚化合物,具有多种⽣物活 性,可作为抗氧化、抗衰⽼、抗菌消炎剂被⼴泛应⽤于多个医学领域。 |
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体外研究 |
Protocatechualdehyde (PCA) (50, 100μM, 24/48 hours ) treated MCF-7 cells significantly decrease cell growth by 11% and 20% in 24 hours and by 22% and 27% in 48 hours, respectively. Protocatechualdehyde (50, 100μM, 24 hours) treated MCF-7 cells are increased by 1.9-fold and 2.6-fold in the concentrations of 50μM and 100μM, respectively. PCA suppresses proliferation of estrogen receptor (ER)-positive (MCF-7) breast cancer cells, but not ER-negative (MDA-MB-231) breast cancer cells. Protocatechualdehyde (0, 100, 200μM, 48 hours in HCT116 and SW480 cells) affects the enzyme activity of HDAC and observed that PCA treatment resulted in inhibition of HDAC activity in dose-dependent manner Cell Proliferation Assay |
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Cell Line: |
Human breast cancer cell (MCF-7 and MDA-MB-231) |
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Concentration: |
0, 5, 10, 25, 50, and 100μM |
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Incubation Time: |
24, 48 hours |
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Result: |
Inhibited MCF-7 cells cell growth. |
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Apoptosis Analysis |
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Cell Line: |
Human breast cancer cell (MCF-7 and MDA-MB-231) |
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Concentration: |
0, 5, 10, 25, 50, and 100μM |
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Incubation Time: |
24, 48 hours |
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Result: |
Increased apoptosis in MCF-7 cells. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )