桉树醇 - CAS:470-82-6 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	桉树醇促销
英文名称:	Cineole
别名:	1,8-桉叶素 Cineole
CAS No:	470-82-6	分子式:	C₁₀H₁₈O	分子量:	154.25
CAS No:	470-82-6
分子式:	C₁₀H₁₈O
分子量:	154.25
MDL:	MFCD00167977	EINEC:	207-431-5
EINEC:	207-431-5

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF) 点击下载技术规格说明书(PDF)

C70262 桉树醇 99% (psaitong)

相关产品

熔点：

1.5℃

密度：

0.921g/mL

包装规格：

100mL 500mL 2.5L in glass bottle

溶解性：

溶于12-15倍容积的50%乙醇,4倍的60%乙醇,1.5-2倍的70%乙醇,溶于氯仿、乙酸及挥发油,微溶于乙醚。

产品描述：

基本信息

产品编号：	C70262
产品名称：	Cineole
CAS:	470-82-6	储存条件	粉末	室温	四年

分子式：	C10H18O		溶于液体	-20℃	两年
分子量	154.25
化学名：	1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane
Solubility (25°C)：
体外:	DMSO	≥ 120mg/mL (777.96mM)
	Ethanol
	Water	30mg/mL (194.4895mM; Need ultrasonic)
体内(现配现用):	1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 3.5mg/mL (22.69mM); Clear solution
	此⽅案可获得 ≥ 3.5mg/mL (22.69mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 35.0mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50μL Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。
	2.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 3.5mg/mL (22.69mM); Clear solution
	此⽅案可获得 ≥ 3.5mg/mL (22.69mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 35.0mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。
	3.请依序添加每种溶剂：10% DMSO→90% corn oil Solubility: ≥ 3.5mg/mL (22.69mM); Clear solution
	此⽅案可获得 ≥ 3.5mg/mL (22.69mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。以 1mL ⼯作液为例，取 100μL 35.0mg/mL 的澄清 DMSO 储备液加到 900μL ⽟⽶油中，混合均匀。
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	6.4830mL	32.4149mL	64.8298mL
5mM	1.2966mL	6.4830mL	12.9660mL
10mM	0.6483mL	3.2415mL	6.4830mL

生物活性

产品描述	Eucalyptol 是 5-HT3 受体, 钾通道, TNF-α 和 IL-1β 的抑制剂。
靶点	5-HT3 Receptor	IL-1β	TNF-α	potassium channel
体外研究	Eucalyptol inhibits 5-HT-evoked currents in oocytes expressing 5-HT3 receptors with an IC50 of 258μM. Eucalyptol (Cin) treatment significantly decreases the ROS level in Aβ_25-35 treated cells in a dose dependent manner. Eucalyptol treatment significantly decreases the NO level in Aβ_25-35 treated cells in a dose dependent manner (p<0.01). Eucalyptol treatment also significantly decreases IL-1βlevel in Aβ_25-35 treated cells in a dose dependent manner (p<0.01) as compare to Aβ_25-35 treated PC12 cells. IL-6 level is also attenuated by Eucalyptol in dose dependent manner (p<0.01) as compare to Aβ_25-35 treated cells
体内研究	Results show that male and female rats treated with Eucalyptol (CIN) at the highest doses, 500 and 1000mg/kg, have shown lower body weight than control group from the 7th to 50th day of treatment. The administration of Eucalyptol significantly reduces body weight gain of male rats (Eucalyptol 500 and 1000mg/kg) and female rats (Eucalyptol 1000mg/kg) in the first week of treatment. However, this reduction is followed by an increase in body weight of rats males and females treated with all doses of the second week until the end of treatment. For male rats, there is a significant increase of 6.93% in mean corpuscular volume (MCV) (Eucalyptol 1000mg/kg) and of 43.54 and 38.98% in the platelet count (Eucalyptol 500 and 1000mg/kg, respectively) and a decrease of 6.74 and 6.67% in mean corpuscular hemoglobin concentration (MCHC) (Eucalyptol 500 and 1000mg/kg) and mean platelet volume (MPV) of 10.40, 10.60 and 15.73% (Eucalyptol 100, 500 and 1000mg/kg, respectively), when compare to the control group

推荐实验方法(仅供参考)

Cell Assay

The protective dose of Eucalyptol (Cineole) is determined by MTT dye-uptake method. In brief, cells (1×10⁴ per well) are seeded in 96-well tissue culture plates and allowed to adhere for 24 h in CO2 incubator at 37°C. Cells are differentiated for the indicated time period. Thereafter, the medium is replaced with the medium containing Eucalyptol (0 to 10μM) in different experiments for a period up to 24 h. Tetrazolium bromide salt (5mg/mL of stock in PBS) 10μL/well is added in 100mL of cell suspension and plate is incubated for 4 h. At the end of incubation period, the reaction mixture is carefully taken out and 200μL of DMSO is added to each well by pipetting up and down several times until the content gets homogenized. The plates are kept on rocker shaker for 10 min at room temperature and then read at 550nm using microplate reader

Animal

Administration

Swiss mice are used in this experiment. The animals are randomly divided into two groups (n=5) and fasted overnight with free access to water. The group control receives a 1% Tween-80 aqueous solution (0.1mL/10 g) and the other group is treated with Eucalyptol a single 2000mg/kg dose by oral route. The animals are observed at 30, 60, 120, 180 and 240 min after oral treatment and daily for 14 days. Behavioral changes, weight, food and water consumption, clinical signs of toxicity or mortality are recorded daily

保存条件：

室温

UN码：

HazardClass：

危害声明：

安全说明：

点击下载核磁/氢谱图谱(PDF)

点击下载高效液相/气相图谱(PDF)

搜索质检报告(COA)

参考文献 & 客户发表文献