| 中文名称: | Cirsiliol | ||||
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| 英文名称: | Cirsiliol | ||||
| 别名: | Cirsiliol 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one | ||||
| CAS No: | 34334-69-5 | 分子式: | C17H14O7 | 分子量: | 330.29 |
| CAS No: | 34334-69-5 | ||||
| 分子式: | C17H14O7 | ||||
| 分子量: | 330.29 | ||||
基本信息
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产品编号： |
C70137 |
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产品名称： |
Cirsiliol |
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CAS: |
34334-69-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
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分子量 |
330.29 |
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化学名： |
2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one |
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生物活性
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产品描述 |
有效和选择性的5-脂氧合酶(5-lipoxygenase)抑制剂，并且是竞争性低亲和力的苯二氮卓受体配体。 |
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靶点 |
5-Lipoxygenase |
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体外研究 |
In concentrations from 0.01 to 300μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca2+ influx but stimulates Ca2+ release from intracellular stores[1]. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression |
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体内研究 |
In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone |
推荐实验方法(仅供参考)
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Cell Assay |
NSCLC, NCI-H1299, NCI-H460, WI-26 VA4 and MRC-5 cell lines are exposed to a single dose of γ-rays. Cells are then treated with rhamnetin and cirsiliol (5, 10, 15, 20, 25μM) dissolved in DMSO for 4h |
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Animal Administration |
Mice BALB/c athymic nude mice are injected with 2×106 NCI-H1299 cells. When the tumor has acquired a minimal volume of 200mm3 , DMSO or Cirsiliol (200μg/kg body weight) is administered intraperitoneally every day for 25 days. The animals are also irradiated with 10 Gy once a week for 3 weeks. On day 25, the tumors are excised and subjected to further analyses |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
