| 中文名称: | CGP 65015 | ||||
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| 英文名称: | CGP 65015 | ||||
| 别名: | 3-Hydroxy-1-(2-hydroxyethyl)-2-(hydroxyphenylmethyl)-4(1H)-pyridinone | ||||
| CAS No: | 189564-33-8 | 分子式: | C14H15NO4 | 分子量: | 261.27 |
| CAS No: | 189564-33-8 | ||||
| 分子式: | C14H15NO4 | ||||
| 分子量: | 261.27 | ||||
基本信息
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产品编号： |
C11720 |
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产品名称： |
CGP 65015 |
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CAS: |
189564-33-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
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分子量 |
261.27 |
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化学名： |
3-Hydroxy-1-(2-hydroxyethyl)-2-(hydroxyphenylmethyl)-4(1H)-pyridinone |
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生物活性
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产品描述 |
一种可口服的铁螯合剂，可以清除铁沉积。 |
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靶点 |
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体外研究 |
CGP 65015 is an oral iron chelator |
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体内研究 |
CGP65015 (150μmol IBE/kg p.o. on d0) dramatically increases the urinary and faecal iron clearance, and still enhances iron elimination during the second post-treatment day in iron-overloaded marmosets |
推荐实验方法(仅供参考)
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Animal Administration |
Marmosets To approximate the iron status of thalassaemic patients in the marmosets, the animals are iron-overloaded by three i.p. injections of iron (III) hydroxide polyisomaltose at 14-d intervals (200mg/kg twice and 100mg/kg at the third injection). Prior to the first exposure to an iron chelator (CGP 65015), the marmosets are rested for at least 8 weeks in order to allow definite distribution of the injected iron into all storage compartments. CGP 65015 is dispersed in 40% aqueous Cremophor RH 40 for oral administration of 150μmol IBE/kg. All dosages are expressed in terms of 'iron binding equivalents' (IBE) which take into account the stoichiometry of the chelator in the iron complex, i.e. 150μmol IBE correspond to 150, 300 and 450μmol of a mono-, bi- and tridentate chelator respectively. The standard dose is 150μmol iron binding equivalents (IBE) per kg body weight. The applied volume is 5 mL/kg body weight |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
