中文名称: α-胡萝卜素
英文名称: α-Carotene
CAS No: 7488-99-5
分子式: C40H56
分子量: 536.87
C11589 α-胡萝卜素 ≥95% (psaitong)
包装规格:
5mg in glass bottle
产品描述:

基本信息

产品编号:

C11589

产品名称:

α-Carotene

CAS:

7488-99-5

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C40H56

溶于液体

-80℃

六个月

分子量

536.87

-20℃

一个月

化学名: 

1,3,3-Trimethyl-2-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-((R)-2,6,6-trimethylcyclohex-2-en-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl)cyclohex-1-ene

 

生物活性

产品描述

维生素 A 的前体,用作抗转移剂或用作抗癌药的佐剂。α-Carotene 是从橙黄色和深绿色蔬菜中分离出来的。

体外研究

α-Carotene (0.5-2.5μM; 24 hours) significantly increases protein expression of TIMP-1 and TIMP-2 in a concentrationdependent manner in LLC cells. AC (0.5-2.5μM) significantly increases PAI-1 protein expression. α-Carotene (2.5μM) also significantly inhibits integrin β1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family.

α-Carotene (0.5, 1, 2.5μM; 48 hours) significantly and concentration-dependently inhibits invasion of LLC during 48 h of incubation.

α-Carotene (0.5, 1, 2.5μM; 24 hours) significantly decreases activities of MMP-9, -2 and uPA in concentration-dependent manner in LLC cells.

α-Carotene (2, 5, 10μM; 7 days) inhibits the proliferation of the human neuroblastoma cell line GOTO in a dose- and timedependent manner. α-Carotene (5μM; 48 hours) halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc

Western Blot Analysis

Cell Line:

Lewis lung carcinoma (LLC) cells

Concentration:

0.5, 1, 2.5μM

Incubation Time:

24 hours

Result:

Significantly increased protein expression of TIMP-1 and TIMP-2 in a concentration-dependent manner in LLC cells.

体内研究

α-Carotene (5 mg/kg; oral; twice a week; for additional 3 weeks) alone significantly decreases lung metastasis without affecting primary tumor growth

Animal Model:

C57BL/6 male mice (4 weeks old; 20-25 g) with LLC cells

Dosage:

5 mg/kg

Administration:

Oral; twice a week; for additional 3 weeks

Result:

Significantly decreased lung metastasis.

保存条件:
-20℃ 避光 充氮保存 真空环境
UN码:
HazardClass:
危害声明:
安全说明:
搜索质检报告(COA)
参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

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    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):