| 中文名称: | CGP71683 hydrochloride | ||||
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| 英文名称: | CGP71683 hydrochloride | ||||
| 别名: | N-(((1R,4R)-4-(((4-氨基喹唑啉-2-基)氨基)甲基)环己基)甲基)萘-1-磺酰胺盐酸盐 N-(((1r,4r)-4-(((4-aminoquinazolin-2-yl)amino)methyl)cyclohexyl)methyl)naphthalene-1-sulfonamide hydrochloride | ||||
| CAS No: | 192322-50-2 | 分子式: | C26H30ClN5O2S | 分子量: | 512.07 |
| CAS No: | 192322-50-2 | ||||
| 分子式: | C26H30ClN5O2S | ||||
| 分子量: | 512.07 | ||||
基本信息
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产品编号： |
C11527 |
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产品名称： |
CGP71683 hydrochloride |
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CAS: |
192322-50-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
512.07 |
-20℃ |
1个月 |
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化学名： |
N-(((1r,4r)-4-(((4-aminoquinazolin-2-yl)amino)methyl)cyclohexyl)methyl)naphthalene-1-sulfonamide hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
100mg/mL (195.28mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
1.9529mL |
9.7643mL |
19.5286mL |
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5mM |
0.3906mL |
1.9529mL |
3.9057mL |
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10mM |
0.1953mL |
0.9764mL |
1.9529mL |
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50mM |
0.0391mL |
0.1953mL |
0.3906mL |
生物活性
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产品描述 |
一种竞争性的神经肽受体 (neuropeptide Y5 receptor) 拮抗剂。 |
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靶点 |
Y5 receptor |
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1.3nM(Ki) |
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体外研究 |
CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3nM,and shows no obvious activity at Y1 receptor (Ki,>4000nM) and Y2 receptor (Ki,200nM) in cell membranes. |
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体内研究 |
CGP71683 (15nmol/rat,icv,twice daily) shows anorexigenic effect,reducing food intake and bady weight of fed rats.CGP71683 causes 3-times higher serum total T4 and 37% increase in free T4 in the fasted rats than in the fasted controls rats. |
推荐实验方法(仅供参考)
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动物实验: |
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Rats CGP71683 is dissolved in 30% DMSO and kept frozen at -20℃ until the experiment.Each microinjection consists of 2μL of either vehicle (30% DMSO) or CGP71683 (7.5nmol/μL;15nmol/rat) injected during 30-60s through the guide cannula,as the following protocols:I-rats with free access to chow receive 6 microinjections (15nmol/rat,10-14h interval between each one) and are killed 1h after the last injection,between 9 and 10a.m.Food intake is estimated by the reduction in chow mass (g),evaluated daily,immediately before each icv injection.II-72h-fasted rats receive a single microinjection of vehicle or CGP71683 (15nmol/rat) and sacrificed 1h latter.III - during a period of 72h of fasting,rats are treated with multiple injections of vehicle or CGP71683 with the same protocol used for fed animals,and the fasting period started 10h before the first microinjection.At the end of experimental protocols,rats are decapitated and serum is obtained from trunk blood for the measurement of the concentrations of hormones. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
