| 中文名称: | 6-(4-(叔丁基)苯氧基)吡啶-3-胺 | ||||
|---|---|---|---|---|---|
| 英文名称: | 6-(4-(tert-Butyl)phenoxy)pyridin-3-amine | ||||
| 别名: | 6-(4-(叔丁基)苯氧基)吡啶-3-胺 CB-103 | ||||
| CAS No: | 218457-67-1 | 分子式: | C15H18N2O | 分子量: | 242.322 |
| CAS No: | 218457-67-1 | ||||
| 分子式: | C15H18N2O | ||||
| 分子量: | 242.322 | ||||
包装规格：
10mg 100mg 500mg in glass bottle
溶解性：
溶于DMSO（250mg/mL超声）
产品描述：
一种首创的，有口服活性的蛋白相互作用 (PPI) 抑制剂，靶向 NOTCH 转录复合体，具有抗肿瘤活性。
CB-103 is a γ-secretase inhibitor. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis, thereby impairing proliferation, including in GSI-resistant human tumor cell lines with chromosomal translocations and rearrangements in Notch genes. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts, notably without causing the dose-limiting intestinal toxicity associated with other Notch inhibitors.
CB-103 is a γ-secretase inhibitor. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis, thereby impairing proliferation, including in GSI-resistant human tumor cell lines with chromosomal translocations and rearrangements in Notch genes. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts, notably without causing the dose-limiting intestinal toxicity associated with other Notch inhibitors.
保存条件：
-20℃
UN码：
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危害声明：
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参考文献 & 客户发表文献
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
