| 中文名称: | Ciliobrevin D | ||||
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| 英文名称: | Ciliobrevin D | ||||
| 别名: | Ciliobrevin D 2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile | ||||
| CAS No: | 1370554-01-0 | 分子式: | C17H8Cl3N3O2 | 分子量: | 392.62 |
| CAS No: | 1370554-01-0 | ||||
| 分子式: | C17H8Cl3N3O2 | ||||
| 分子量: | 392.62 | ||||
基本信息
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产品编号： |
C11392 |
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产品名称： |
Ciliobrevin D |
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CAS: |
1370554-01-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
392.62 |
-20℃ |
1个月 |
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化学名： |
2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile |
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Solubility (25°C)： |
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体外:
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DMSO |
20mg/mL (50.93mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.5470mL |
12.7350mL |
25.4699mL |
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5mM |
0.5094mL |
2.5470mL |
5.0940mL |
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10mM |
0.2547mL |
1.2735mL |
2.5470mL |
生物活性
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产品描述 |
一种细胞渗透性，可逆和特异性的AAA+ATPase运动细胞质动力蛋白抑制剂。Ciliobrevin D抑制Hedgehog (Hh)信号和初级纤毛形成。Ciliobrevin D在体外抑制依赖于动力蛋白的微管滑动和ATPase活性。 |
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靶点 |
Cytoplasmic dynein |
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体外研究 |
Cells treated with Ciliobrevin D exhibits abnormal (unfocused,multipolar,or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells.Similar Ciliobrevin-induced spindle defects are observed in HeLa cells,although to a lesser extent.Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels.Ciliobrevin D reversibly inhibits melanosome aggregation,but the non-cilia-disrupting derivative had no discernible effect at comparable doses.Ciliobrevin D similarly abrogates the movement of peroxisomes in Drosophila S2 cells. |
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体内研究 |
Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D in the testis in vivo perturbs spermatogenesis.Knockdown of Dync1h1 or the use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1,perturbs F-actin organization,and perturbs distribution of adhesion protein complexes at the BTB,leading to a loss of BTB integrity.F-actin disorganization in the seminiferous epithelium following Dync1h1 knockdown or dynein 1 inactivation by Ciliobrevin D is mediated by changes in the spatiotemporal expression of actin regulatory proteins Arp3 and Eps8. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
