Casein Kinase II Inhibitor IV Hydrochloride - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Casein Kinase II Inhibitor IV Hydrochloride
英文名称:	Casein Kinase II Inhibitor IV Hydrochloride
别名:	Casein Kinase II Inhibitor IV Hydrochloride Casein Kinase II Inhibitor IV Hydrochloride
CAS No:		分子式:	C₂₄H₂₄ClN₅O₃	分子量:	465.93
CAS No:
分子式:	C₂₄H₂₄ClN₅O₃
分子量:	465.93

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C11388 Casein Kinase II Inhibitor IV Hydrochloride (psaitong)

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包装规格：

100mg 250mg 1g in glass bottle

产品描述：

基本信息

产品编号：C11388
产品名称：Casein Kinase II Inhibitor IV Hydrochloride
CAS:		储存条件	粉末	-20℃	四年
分子式：	C24H24ClN5O3
分子量	465.93
化学名：
Solubility (25°C)	体外	DMSO
		Ethanol
		Water
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

生物活性

产品描述

表皮角质形成细胞分化的小分子诱导剂。

靶点/IC₅₀

Target: Casein Kinase

体外研究

Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expresses loricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes.

推荐实验方法(仅供参考)

激酶实验：

Kinase Assay

For reporter gene assays with transiently transfected cells, the cells are typically transfected in 150mm-diam dishes when 30-40% confluent. A reporter plasmid, pGL3/3.7 kbp-IVLLuc plasmid, is transfected into the human epidermal keratinocytes(NHEKs). After 24 h, the transfected cells are plated into 96-well assay plates and treated with Casein Kinase II Inhibitor IV to a final concentration of 5μM. After incubation for 2 d, reporter gene activity is measured using the Bright-Glo luciferase assay system.

保存条件：

-20℃

UN码：

HazardClass：

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安全说明：

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