中文名称: | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate | ||||
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英文名称: | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate | ||||
别名: | Cinnamyl-3,4-dihydroxy-α-cyanocinnamate CDC | ||||
CAS No: | 132465-11-3 | 分子式: | C19H15NO4 | 分子量: | 321.33 |
CAS No: | 132465-11-3 | ||||
分子式: | C19H15NO4 | ||||
分子量: | 321.33 |
基本信息
产品编号: |
C11235 |
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产品名称: |
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate |
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CAS: |
132465-11-3 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
321.33 |
-20℃ |
一个月 |
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化学名: |
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-,3-phenyl-2-propen-1-yl ester, (2E)- |
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Solubility (25°C): |
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体外:
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DMSO |
50mg/mL(155.60mM;Need ultrasonic) |
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Ethanol |
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Water |
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体内(现配现用): |
1.请依序添加每种溶剂:10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility:≥2.5mg/mL(7.78mM);Clear solution |
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此⽅案可获得≥2.5mg/mL(7.78mM,饱和度未知)的澄清溶液。以1mL⼯作液为例,取100μL25.0mg/mL的澄清DMSO储备液加到400μL PEG300中,混合均匀;向上述体系中加⼊50μL Tween-80,混合均匀;然后继续加⼊450μL⽣理盐⽔定容⾄1mL。 |
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2.请依序添加每种溶剂:10% DMSO→90% (20% SBE-β-CD in saline) Solubility:≥2.5mg/mL(7.78mM);Clear solution |
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此⽅案可获得≥2.5mg/mL(7.78mM,饱和度未知)的澄清溶液。以1mL⼯作液为例,取100μL25.0mg/mL的澄清DMSO储备液加到900μL20%的SBE-β-CD⽣理盐⽔⽔溶液中,混合均匀。 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.1121mL |
15.5603mL |
31.1207mL |
5mM |
0.6224mL |
3.1121mL |
6.2241mL |
10mM |
0.3112mL |
1.5560mL |
3.1121mL |
生物活性
产品描述 |
一种有效的12/15脂氧合酶(12/15-LO)抑制剂。Cinnamyl-3,4-dihydroxy-α-cyanocinnamate可用于研究1型糖尿病。 |
体外研究 |
High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further. Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport |
体内研究 |
The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐ catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )