中文名称: | CLoperastine fendizoate | ||||
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英文名称: | CLoperastine fendizoate | ||||
别名: | 氯苄哌醚联苯酰苯酸盐;1-(2-((4-氯苯基)(苯基)甲氧基)乙基)哌啶 2-(6-羟基-[1,1'-联苯]-3-羰基)苯甲酸盐 o-[(2'-hydroxy[1,1'-biphenyl]-4-yl)carbonyl]benzoic acid, compound with 1-[2-(4-chlorobenzhydryloxy)ethyl]piperidine (1:1);Cloperastine Fendizoate;1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,2-(4-hydroxy-3-phenylbenzoyl)benzoic acid | ||||
CAS No: | 85187-37-7 | 分子式: | C40H38ClNO5 | 分子量: | 648.19 |
CAS No: | 85187-37-7 | ||||
分子式: | C40H38ClNO5 | ||||
分子量: | 648.19 |
基本信息
产品编号: |
C11199 |
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产品名称: |
CLoperastine fendizoate |
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CAS: |
85187-37-7 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
648.19 |
-20℃ |
1个月 |
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化学名: |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.5428mL |
7.7138mL |
15.4276mL |
5mM |
0.3086mL |
1.5428mL |
3.0855mL |
10mM |
0.1543mL |
0.7714mL |
1.5428mL |
生物活性
产品描述 |
一种抑制hERGK+电流,IC50为27nM,这种作用具有浓度依赖性。 |
靶点 |
27nM (K+currents) |
体外研究 |
Cloperastine inhibits the hERG K+ currents in a concentrationdependent manner with IC50 value of 27±3nM.Among the antitussive agents,Cloperastine,which possesses antitussive and antiedemic activity,also relaxes the bronchial musculature.Cloperastine is a drug with a central antitussive effect,and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects. |
体内研究 |
In the anesthetized guinea pigs,Cloperastine at a therapeutic dose of 1mg/kg prolonged the QT interval and monophasicaction potential (MAP) duration without affecting PR interval or QRS width.Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice,and shows minor toxicity by the oral route when administered as Cloperastine fendizoate,the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000mg/kg,respectively. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )