| 中文名称: | 盐酸可乐定 促销 | ||||
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| 英文名称: | Clonidine hydrochloride | ||||
| 别名: | 盐酸可乐定 Clonidine hydrochloride | ||||
| CAS No: | 4205-91-8 | 分子式: | C9H9Cl2N3.HCl | 分子量: | 266.55 |
| CAS No: | 4205-91-8 | ||||
| 分子式: | C9H9Cl2N3.HCl | ||||
| 分子量: | 266.55 | ||||
| MDL: | MFCD00036705 | EINEC: | 224-121-5 | ||
| EINEC: | 224-121-5 | ||||
基本信息
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产品编号： |
C110971 |
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产品名称： |
Clonidine hydrochloride |
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CAS: |
4205-91-8 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
266.55 |
-20℃ |
1个月 |
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化学名： |
N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
53mg/mL (198.87mM) |
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Ethanol |
53mg/mL (198.87mM) |
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Water |
53mg/mL (198.87mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.7523mL |
18.7617mL |
37.5235mL |
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5mM |
0.7505mL |
3.7523mL |
7.5047mL |
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10mM |
0.3752mL |
1.8762mL |
3.7523mL |
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50mM |
0.0750mL |
0.3752mL |
0.7505mL |
生物活性
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产品描述 |
是 α2-adrenoceptor 激动剂，为一种有效的抗高血压药。 |
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靶点 |
α2-adrenergic receptor |
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体外研究 |
Clonidine (0.01,0.1 or 1μM) significantly induces CGRP (α and β) mRNA expression in a dose-dependent manner in endothelial cells.Clonidine treatment (1μM) for 24h significantly increases the NO level in endothelial cells.NO pathway modulates CGRP production induced by clonidine. |
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体内研究 |
Clonidine (50μg/kg,i.p.) induces a significant decrease in body temperature of rat lasting 3hr,with the maximum at 1hr after administration.An intracerebroventricular pretreatment of rats with neutral doses of phentolamine 15 min before clonidine considerably antagonizes the clonidine-induced hypothermia.Clonidine (0.003-0.05mg/kg,i.p.) potently suppresses dopamine efflux in the prefrontal cortex induced by PCP.Pretreatment with the alpha-2A receptor antagonist (BRL-44408) prevents clonidine from suppressing PCP-induced dopamine overflow in the prefrontal cortex.In DMSOpretreated SO rats,clonidine (0.6μg i.c.) has no effect on blood pressure.However,after central adenosine A1R blockade (DPCPX) in SO rats,clonidine significantly (P<0.05,one-way ANOVA) reduces blood pressure. In contrast,in DMSOpretreated ABD rats,clonidine (0.6μg i.c.) causes significant reduction in blood pressure;importantly, central A1R blockade (DPCPX pretreatment) does not influence (P>0.05,one-way ANOVA) clonidine-evoked reduction in blood pressure in ABD rats.In DPCPX-pretreated SO rats and along with the appearance of the hypotensive response,clonidine causes a significant (P<0.05) increase in the RVLM pERK1/2 level compared with basal or clonidine treatment in DMSO-pretreated SO rats.In vehicle (DMSO)-pretreated ABD rats,clonidine significantly (P<0.05) enhances RVLM pERK1/2,and this response is not affected by DPCPX pretreatment. |
推荐实验方法(仅供参考)
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动物实验: |
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On the day of the experiment,the flow rate is increased to 2μL/min approximately 2h before beginning the collection of baseline samples.Dialysates are collected every 20 min;after 4 baseline samples are collected,animals are pretreated with an intra-peritoneal (i.p.) injection of either 0.9% saline (the vehicle),clonidine (0.0033,0.01 or 0.05mg/kg) or guanfacine (0.05 or 0.5mg/kg),before receiving an injection of PCP (2.5mg/kg,i.p.) 20 min later.In a separate study,BRL (1.0mg/kg) is administered 20 min prior to clonidine.In addition, for some control experiments,the animals only receive one injection of saline,clonidine (0.01 or 0.05mg/kg),guanfacine (0.5mg/kg) or BRL (1.0mg/kg). |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
