Casein Kinase II Inhibitor IV - CAS:863598-09-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	Casein Kinase II Inhibitor IV
英文名称:	Casein Kinase II Inhibitor IV
CAS No:	863598-09-8	分子式:	C₂₄H₂₃N₅O₃	分子量:	429.47
CAS No:	863598-09-8
分子式:	C₂₄H₂₃N₅O₃
分子量:	429.47

安全技术说明书(PDF) MSDS(PDF) 点击下载产品说明书(PDF)

C10900 Casein Kinase II Inhibitor IV ≥98% (psaitong)

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包装规格：

5mg in glass bottle

溶解性：

溶于DMSO（33.33 mg/mL 超声）

产品描述：

基本信息

产品编号：C10900
产品名称：Casein Kinase II Inhibitor IV
CAS:	863598-09-8	储存条件	粉末	-20℃	四年
分子式：	C24H23N5O3		溶于液体	-80℃	两年
分子量	429.47
化学名：	3-[3-[2-(3,4,5-trimethoxyanilino)pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]propanenitrile
Solubility (25°C)	体外	DMSO	30mg/mL (69.85mM; Need ultrasonic
		Ethanol
		Water
	体内	现配现用
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.3285mL	11.6423mL	23.2845mL
5mM	0.4657mL	2.3285mL	4.6569mL
10mM	0.2328mL	1.1642mL	2.3285mL

生物活性

产品描述

表皮角质形成细胞分化的小分子诱导剂。

靶点/IC₅₀

Target: Casein Kinase

体外研究

Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expressesloricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are again consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes.

推荐实验方法(仅供参考)

激酶实验：

Kinase Assay

For reporter gene assays with transiently transfected cells, the cells are typically transfected in 150mm-diam dishes when 30-40% confluent. A reporter plasmid, pGL3/3.7 kbp-IVLLuc plasmid, is transfected into the NHEKs. After 24 h, the transfected cells are plated into 96-well assay plates and treated with compound (Casein Kinase II Inhibitor IV) to a final concentration of 5μM. After incubation for 2 d, reporter gene activity is measured using the Bright-Glo luciferase assay system

保存条件：

-20℃

UN码：

HazardClass：

危害声明：

安全说明：

搜索质检报告(COA)

参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果