CITCO - CAS:338404-52-7 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	CITCO 促销
英文名称:	CITCO
别名:	6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime
CAS No:	338404-52-7	分子式:	C₁₉H₁₂N₃OCl₃S	分子量:	436.74
CAS No:	338404-52-7
分子式:	C₁₉H₁₂N₃OCl₃S
分子量:	436.74
MDL:	MFCD00139608

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C10837 CITCO ≥98% (psaitong)

相关产品

包装规格：

5mg in glass bottle

产品描述：

基本信息

产品编号：C10837
产品名称：CITCO
CAS:	338404-52-7	储存条件	粉末	-20℃	四年
分子式：	C19H12N3OCl3S		溶于液体	-80℃(远离湿气）	六个月
分子量	736.74			-20℃(远离湿气）	一个月
化学名：
Solubility (25°C)	体外	DMSO	87mg/mL (199.2mM)
		Ethanol	Insoluble
		Water	Insoluble
	体内（现配现用）
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.2897mL	11.4485mL	22.8969mL
5mM	0.4579mL	2.2897mL	4.5794mL
10mM	0.2290mL	1.1448mL	2.2897mL
50mM	0.0458mL	0.2290mL	0.4579mL

生物活性

产品描述	一种组成型雄甾烷 (Constitutive androstane) 受体激动剂，抑制脑肿瘤干细胞 (BTSCs) 的生长和扩增。
靶点/IC₅₀	CAR (in CAR/SRC-1 FRET assay)
靶点/IC₅₀	49nM(EC50)
体外研究	CITCO (1-50μM; 48 hours) results in a dose-dependent inhibition of viable cell count and proliferation in both T98G and U87MG glioma and BTSCs.CITCO (2.5, 5μM; 48 hours) induces cell cycle arrest differentially in different BTSCs in culture, but not in normal astrocytes.CITCO (2.5-10μM; 48 hours) induces apoptosis in BTSCs in culture in dose dependently, but not in normal astrocytes.CITCO (0-25μM; 48 hours) causes the T98G and U87MG glioma and BTSCs expressing very low levels of CAR protein that increased significantly. Cell Proliferation Assay
	Cell Line:	T98G, U87MG, DB29 and DB33 human glioma cells, astrocytes
	Concentration:	1, 2.5, 5, 10, 25, 50μM
	Incubation Time:	48 hours
	Result:	Resulted in a dose-dependent inhibition of viable cell count and proliferation.
	Cell Cycle Analysis
	Cell Line:	The T98G, U87MG, DB29 and DB33 glioma cells
	Concentration:	2.5, 5μM
	Incubation Time:	48 hours
	Result:	Induced cell cycle arrest differentially in different BTSCs in culture.
	Apoptosis Analysis
	Cell Line:	The T98G, U87MG, DB29 and DB33 glioma cells
	Concentration:	2.5, 5 or 10μM
	Incubation Time:	48 hours
	Result:	Increased the levels of Annexin V-positive apoptotic cells in dose dependently.
	Western Blot Analysis
	Cell Line:	T98G, U87MG, DB29 and DB33 glioma cells
	Concentration:	0 to 25μM
	Incubation Time:	48 hours
	Result:	The T98G, U87MG glioma and BTSCs expressed very low levels of CAR protein that increased significantly.
体内研究	CITCO (intraperitoneal; on days 22, 24, 26, 30 and 36) with 25μg results a significant decrease in tumour growth, which further decreases to an undetectable level after treatment with 100μg CITCO.
	Animal Model:	Six- to eight-week-old male athymic nude mice
	Dosage:	25 or 100μg
	Administration:	Intraperitoneal; on days 22, 24, 26, 30 and 36
	Result:	Decreased tumour growth.