| 中文名称: | CGP52432 促销 | ||||
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| 英文名称: | CGP52432 | ||||
| 别名: | [3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid | ||||
| CAS No: | 139667-74-6 | 分子式: | C15H24Cl2NO4P | 分子量: | 384.24 |
| CAS No: | 139667-74-6 | ||||
| 分子式: | C15H24Cl2NO4P | ||||
| 分子量: | 384.24 | ||||
基本信息
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产品编号： |
C10060 |
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产品名称： |
CGP52432 |
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CAS: |
139667-74-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
384.24 |
-20℃ |
1个月 |
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化学名： |
[3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid |
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Solubility (25°C)： |
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体外:
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DMSO |
5mg/mL (13.01mM) |
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Ethanol |
5mg/mL (13.01mM) |
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Water |
2.5mg/mL (6.5mM) |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.6025mL |
13.0127mL |
26.0254mL |
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5mM |
0.5205mL |
2.6025mL |
5.2051mL |
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10mM |
0.2603mL |
1.3013mL |
2.6025mL |
生物活性
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产品描述 |
一种非常有效的GABAB受体拮抗剂，IC50:85nm。 |
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靶点 |
IC50:85nM (GABAB receptor) |
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体外研究 |
CGP52432 is a GABAB receptor antagonist,with an IC50 of 85nM,35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow,respectively. |
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体内研究 |
CGP52432 (10,30mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze.CGP52432 (100nmol/kg,i.v.,or 1nmol/kg,i.c.v.) abolishes the suppressive effects of GABA ( 50μmol/kg,i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia,causeing elimination of the renoprotective effects of GABA in rats. |
推荐实验方法(仅供参考)
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动物实验: |
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Mice Two separate cohorts of male pups are used for the study.One cohort is treated with either R(+)baclofen HCl (2mg/kg) or with vehicle (PBS).The second cohort is treated with the GABAB receptor antagonist CGP52342 (10,30mg/kg) or vehicle (PBS).Drugs are freshly prepared for injection each day,by dissolution in PBS with vortexing and brief sonication.Doses of R(+)baclofen and CGP52432 are chosen to be well tolerated in adult mice.All drug treatments are given via subcutaneous injection,once daily from P14-28 in a volume of 0.05mL. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
