| 中文名称: | 西米替丁 促销 | ||||
|---|---|---|---|---|---|
| 英文名称: | Cimetidine | ||||
| 别名: | 西咪替丁 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine | ||||
| CAS No: | 51481-61-9 | 分子式: | C10H16N6S | 分子量: | 252.34 |
| CAS No: | 51481-61-9 | ||||
| 分子式: | C10H16N6S | ||||
| 分子量: | 252.34 | ||||
| MDL: | MFCD00133296 | EINEC: | 257-232-2 | ||
| EINEC: | 257-232-2 | ||||
基本信息
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产品编号： |
C10024 |
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产品名称： |
Cimetidine |
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CAS: |
51481-61-9 |
储存条件 |
粉末 |
2-8℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
252.34 |
-20℃ |
1个月 |
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化学名： |
N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine |
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Solubility (25°C)： |
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体外:
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DMSO |
51mg/mL (202.1mM) |
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Ethanol |
4mg/mL (15.85mM) |
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Water |
Insoluble |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
|
1mM |
3.9629mL |
19.8145mL |
39.6291mL |
|
5mM |
0.7926mL |
3.9629mL |
7.9258mL |
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10mM |
0.3963mL |
1.9815mL |
3.9629mL |
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50mM |
0.0793mL |
0.3963mL |
0.7926mL |
生物活性
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产品描述 |
H2的组胺受体拮抗剂，具有抑制胃酸分泌的作用，主要作用于壁细胞上的H2受体，能竞争性抑制组胺，从而抑制胃酸分泌。 |
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靶点 |
Histamine Receptor 0.6μM (Ki) |
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体外研究 |
Cimetidine (SKF-92334),a partial agonist for H2R,has a pharmacological profile different from ranitidine and famotidine,possibly contributing to its antitumor activity on gastrointestinal cancers.Cimetidine had no effect on the uptake and cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells).Cimetidine showed no effect on proliferation,survival,migration and invasion of 3LL cells.Cimetidine reversed MDSCmediated T-cell suppression,and improved IFN-γ production.Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB,a transcriptional activator of NCAM gene expression. |
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体内研究 |
Cimetidine (SKF-92334) reduceS CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen,blood and tumor tissue of tumor-bearing mice.Cimetidine exerts a beneficial effect on periodontal disease in rats,decreasing the RANKL/OPG ratio in gingival connective tissue and reducing alveolar bone resorption. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
