中文名称: | BD1063 dhydrochloride | ||||
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英文名称: | BD1063 dhydrochloride | ||||
别名: | 1-(3,4-二氯苯乙基)-4-甲基哌嗪二盐酸盐 1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride, BD1063 dihydrochloride | ||||
CAS No: | 206996-13-6 | 分子式: | C13H18Cl2N2.2HCl | 分子量: | 346.12 |
CAS No: | 206996-13-6 | ||||
分子式: | C13H18Cl2N2.2HCl | ||||
分子量: | 346.12 |
基本信息
产品编号: |
B70156 |
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产品名称: |
BD1063 dhydrochloride |
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CAS: |
206996-13-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
346.12 |
-20℃ |
1个月 |
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化学名: |
1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride, BD1063 dihydrochloride |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.8892mL |
14.4459mL |
28.8917mL |
5mM |
0.5778mL |
2.8892mL |
5.7783mL |
10mM |
0.2889mL |
1.4446mL |
2.8892mL |
生物活性
产品描述 |
一种有效选择性的sigma 1受体拮抗剂。 |
靶点 |
Sigma Receptor |
体内研究 |
BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11mg/kg) and withdrawn,dependent Wistar rats (4-11mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls.BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule.BD1063 dose-dependently reduces binge-like eating and the regularity of food responding,and blocks the increased eating rate in Palatable rats.In the light/dark conflict test,BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet,without affecting motor activity.The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice.Moreover,the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia. |
推荐实验方法(仅供参考)
动物实验: |
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Rats:BD1063 is solubilized in isotonic saline and injected subcutaneously (s.c.1ml/kg),15 min before testing.Rats are pretreated with BD1063 (0,4.4,7 and 11mg/kg of body weight,free base weights,s.c.) using a within-subject Latin square design.sP rats:Rats are pretreated with BD1063 (0,3,4.4,7 and 11mg/kg of body weight,free base basis,s.c.) using a within-subject Latin square design. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )