中文名称: | BIP-135 促销 | ||||
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英文名称: | BIP-135 | ||||
别名: | BIP-135 3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione | ||||
CAS No: | 941575-71-9 | 分子式: | C21H13BrN2O3 | 分子量: | 421.25 |
CAS No: | 941575-71-9 | ||||
分子式: | C21H13BrN2O3 | ||||
分子量: | 421.25 |
基本信息
产品编号: |
B11529 |
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产品名称: |
BIP-135 |
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CAS: |
941575-71-9 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
421.25 |
-20℃ |
1个月 |
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化学名: |
3-(Benzofuran-3-yl)-4-(5-bromo-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
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Solubility (25°C): |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
生物活性
产品描述 |
一个高效、选择性的,ATP 竞争性的GSK-3 抑制剂,对GSK-3α和GSK-3β 作用的IC50值分别为16nM和21nM。BIP 135具有神经保护作用。 |
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靶点 |
GSK-3α 16nM (IC50) |
GSK-3β 21nM (IC50) |
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体外研究 |
BIP-135 (20-30μM;72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25μM in human SMA fibroblasts.And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.BIP-135 (20μM;48 hours) is a superior neuroprotective agent in the model of oxidative stress. Western Blot Analysis |
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Cell Line: |
Human SMA fibroblasts |
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Concentration: |
20μM,25μM,30μM |
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Incubation Time: |
72 hours |
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Result: |
Led to a 7-fold increase in SMN levels at 25μM. |
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体内研究 |
BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).BIP-135 (75mg/kg;i.p.;daily;from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy. |
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Animal Model: |
Male and female SMN2+/+,SMN2Δ7+/+,Smn+/– mice |
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Dosage: |
75mg/kg |
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Administration: |
Intraperitoneal injection;daily;from postnatal day 0 to 21 |
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Result: |
Caused a modest extension in the median survival of SMA KO animals by two days. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )