| 中文名称: | BML-111 | ||||
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| 英文名称: | BML-111 | ||||
| 别名: | BML-111 (5S,6R)-Methyl 5,6,7-trihydroxyheptanoate | ||||
| CAS No: | 78606-80-1 | 分子式: | C8H16O5 | 分子量: | 192.21 |
| CAS No: | 78606-80-1 | ||||
| 分子式: | C8H16O5 | ||||
| 分子量: | 192.21 | ||||
基本信息
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产品编号： |
B11383 |
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产品名称： |
BML-111 |
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CAS: |
78606-80-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
192.21 |
-20℃ |
一个月 |
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化学名： |
(5S,6R)-Methyl 5,6,7-trihydroxyheptanoate |
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生物活性
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产品描述 |
一种脂蛋白 A4 类似物，是一种脂蛋白 A4 (lipoxin A4) 受体激动剂。BML-111 可抑制血管紧张素转化酶 (ACE) 的活性，并增加血管紧张素转化酶 2 (ACE2) 的活性。BML-111 具有抗血管生成，抗肿瘤和抗炎的特性。 |
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靶点 |
Lipoxin A4 receptor Angiotensin converting enzyme (ACE) |
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体外研究 |
In H22 cells, BML-111 inhibits the production of vascular endothelial growth factor and reduces hypoxia-inducible factor-1α level. BML-111 inhibits leukotriene B4-induced cellular migration with an IC50 of 5nM |
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体内研究 |
BML-111 (1mg/kg; intraperitoneal injection; for 15 days; male Imprinting Control Region mice) treatment suppresses tumorrelated angiogenesis and tumor growth in vivo. BML-111 also enhances the in situ apoptosis while inhibiting macrophage infiltration in tumor tissue. BML-111 protects LPS-induced acute lung injury and LPS/D-GalN-induced acute liver injury. BML-111 represses the activity of ACE, but increases the activity of ACE2. BML-111 decreases the expression levels of ACE, AngII, and AngII type 1 receptor (AT1R), meanwhile increases the levels of ACE2, angiotensin-(1-7) (Ang-1-7), and Mas |
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Animal Model: |
Male Imprinting Control Region mice (5-6-week-old,18-22 g) injected with H22 cells |
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Dosage: |
1mg/kg |
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Administration: |
Intraperitoneal injection; injected 5 minutes before and 4 hours after H22 cell inoculation, then every 12 hours for 2 consecutive days, then daily in an additional 3 days and every other day for the last 10 days |
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Result: |
Suppressed tumor-related angiogenesis and tumor growth in vivo. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
