| 中文名称: | BP 897 | ||||
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| 英文名称: | BP 897 | ||||
| 别名: | N-[4-[4-(2-甲氧基苯基)-1-哌嗪基]丁基]-2-萘甲酰胺单盐酸盐 2-Naphthalenecarboxamide,N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-, hydrochloride (1:1);BP897;N-{4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl}-2-naphthamide hydr ochloride (1:1);N-{4-[4-(2-Methoxyphenyl)piperazin-1-yl]butyl}-2-naphthamide hydrochloride (1:1);N-[4-(4-(2-Methoxyphenyl)piperazinyl)butyl]-2-naphthamide;BP 897 | ||||
| CAS No: | 314776-92-6 | 分子式: | C26H32ClN3O2 | 分子量: | 454 |
| CAS No: | 314776-92-6 | ||||
| 分子式: | C26H32ClN3O2 | ||||
| 分子量: | 454 | ||||
基本信息
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产品编号： |
B10874 |
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产品名称： |
BP 897 |
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CAS: |
314776-92-6 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
二年 |
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分子量： |
454.00 |
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化学名： |
2-Naphthalenecarboxamide,N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-,hydrochloride (1:1);BP897 |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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生物活性
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产品描述 |
一种有效的，选择性的多巴胺D3受体(dopamine D3 receptor)部分激动剂，为较弱的多巴胺D2受体(dopamine D2 receptor)拮抗剂，Ki值分别为0.92nM和61nM，对D1和D4受体的亲和性较低，Ki值分别为3和 0.3µM。 |
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靶点 |
Dopamine Receptor |
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体外研究 |
BP 897 also displays low affinities at D1 and D4 receptors (Ki=3 and 0.3μM,respectively),as well as at α1 andα2 adrenergic receptors (Ki=60 and 83nM,respectively),5HT1A and 5HT7 receptors (Ki=84 and 345nM,respectively),and negligible affinities (Ki>1μM) atmuscarinic,histamine and opiate receptors.In NG 108-15 cells expressing the human D3 receptor,BP 897 inhibits forskolin-induced cyclic AMP accumulation with an EC50 of 1nM.BP 897 activates mitogenesis and this response is antagonized by the preferential D3 receptor antagonist Nafadotride (1μM).BP 897 also partially antagonized the response induced by quinpirole (10nM). |
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体内研究 |
BP 897 (0.05,0.5,1mg/kg;i.p.;30 min before the session) reduces cocaine-seeking behaviour before the first infusion of cocaine,in a dose-dependent manner,at doses similar to those at which BP 897 produced its responses on rotations and cfos expression. |
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Animal Model: |
Male Listar hooded rats |
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Dosage: |
0.05,0.5,1mg/kg |
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Administration: |
i.p.;30 min before the session |
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Result: |
Reduced cocaine-seeking behaviour before the first infusion of cocaine,in a dosedependent manner,at doses similar to those at which BP 897 produced its responses on rotations and c-fos expression. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
