| 中文名称: | BAY 38-7271 | ||||
|---|---|---|---|---|---|
| 英文名称: | BAY 38-7271 | ||||
| CAS No: | 212188-60-8 | 分子式: | C20H21F3O5S | 分子量: | 430.44 |
| CAS No: | 212188-60-8 | ||||
| 分子式: | C20H21F3O5S | ||||
| 分子量: | 430.44 | ||||
包装规格：
25mg 50mg 100mg in glass bottle
产品简介：
一个选择性、高效的大麻素受体CB1/CB2激动剂，对人重组CB1和CB2 作用的Ki值分别为1.85nM和5.96nM。BAY 38-7271具有很强的神经保护特性。
体外研究：
BAY 38-7271 shows only minor interactions at the micromolar range with other binding sites such as adenosine A3 receptor(IC50=7.5 μM), peripheral GABAAbenzodiazepine receptor(IC50= 971 nM), melatonin ML1 receptor (IC50=3.3 μM), and at the monoamine transporter (IC50= 1.7 μM).
体内研究：
BAY 38-7271 (Ed50 = 0.02 mg/kg; i.v. and 0.5 mg/kg; i.p.) induces a potent and dose-de-pendent reduction in core body temperature.
BAY 38-7271 has low physical dependence liability and is not essentially different from that of other cannabinoid CB1 receptor agonists.
BAY 38-7271 (1-1000 ng/kg/h; i.v. infusion; for 4 hours) shows neuroprotective efficacy in the rat SDH model.
BAY 38-7271 also has neuroprotective efficacy in models of transient and permanent occlusion of the middle cerebral artery and brain edema models.
BAY 38-7271 has low physical dependence liability and is not essentially different from that of other cannabinoid CB1 receptor agonists.
BAY 38-7271 (1-1000 ng/kg/h; i.v. infusion; for 4 hours) shows neuroprotective efficacy in the rat SDH model.
BAY 38-7271 also has neuroprotective efficacy in models of transient and permanent occlusion of the middle cerebral artery and brain edema models.
保存条件：
-20℃
注意事项：
1、为了您的安全和健康，请穿实验服并戴一次性手套操作。
2、以上信息仅做参考交流之用。
2、以上信息仅做参考交流之用。
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