中文名称: | BIO-1211 | ||||
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英文名称: | BIO-1211 | ||||
CAS No: | 187735-94-0 | 分子式: | C36H48N6O9 | 分子量: | 708.8 |
CAS No: | 187735-94-0 | ||||
分子式: | C36H48N6O9 | ||||
分子量: | 708.8 |
基本信息
产品编号:B10787 |
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产品名称:BIO-1211 |
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CAS: |
187735-94-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃(密封保存,远离潮湿) |
六个月 |
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分子量 |
708.80 |
-20℃(密封保存,远离潮湿) |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
1.4108mL |
7.0542mL |
14.1084mL |
5mM |
0.2822mL |
1.4108mL |
2.8217mL |
10mM |
0.1411mL |
0.7054mL |
1.4108mL |
生物活性
产品描述 |
一种高度选择性的、具有口服活性的 α4β1 (VLA-4) 抑制剂,其对 α4β1 和 α4β7 的 IC50 值分别为 4nM 和 2μM。 |
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靶点/IC50 |
α4β1 |
α4β7 |
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体外研究 |
BIO-1211 almostly exhibits no activity for α1β1,α5β1, α6β1, αLβ2 and αIIbβ3. |
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体内研究 |
BIO-1211 (5 and 10mg/kg, orally, once every other day) results in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in EAE in a dose-independent manner. BIO-1211 exhibits a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+cells into the cerebral cortex. |
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Animal Model: |
Naive, C57BL/6 mice (male, 8 weeks old, 20-25g weight). |
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Dosage: |
5 and 10mg/kg. |
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Administration: |
Orally once every other day starting the day before immunization until day 21 postimmunization. |
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Result: |
Could prevent the induction of EAE.Significantly delayed the onset of EAE and reduced the severity of clinical EAE compared to the vehicle group.Markedly reduced the expression of both CD11b and CD45 in comparison with the vehicle group.mRNA and soluble form of a subset of target inflammatory cytokines (IFNγ, IL-17, and TNFα) was dramatically decreased. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )