| 中文名称: | 巴他布林 | ||||
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| 英文名称: | Batabulin | ||||
| 别名: | 巴他布林 T138067 | ||||
| CAS No: | 195533-53-0 | 分子式: | C13H7F6NO3S | 分子量: | 371.26 |
| CAS No: | 195533-53-0 | ||||
| 分子式: | C13H7F6NO3S | ||||
| 分子量: | 371.26 | ||||
基本信息
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产品编号：B10738 |
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产品名称：Batabulin |
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CAS: |
195533-53-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
六个月 |
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分子量： |
371.26 |
-20℃ |
一个月 |
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化学名： |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内（现配现用） |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.6935mL |
13.4677mL |
26.9353mL |
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5mM |
0.5387mL |
2.6935mL |
5.3871mL |
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10mM |
0.2694mL |
1.3468mL |
2.6935mL |
生物活性
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产品描述 |
一种抗肿瘤剂，可与 β-微管蛋白同种型的子集共价且选择性地结合，从而破坏微管 (microtubule) 聚合。 |
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靶点/IC50 |
β-tubulin |
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体外研究 |
Batabulin (T138067; 30-300nM; 24 hours; MCF7 cells) treatment shows approximately 25-30% tetraploid (4n) DNA content in cells, indicating an arrest at the G2/M cell-cycle boundary.Batabulin (T138067; 30-300nM; 24-48 hours; MCF7 cells) treatment shows 25-30% apoptosis. After a 48-hr exposure to 100nM Batabulin, approximately 50-80% of the cell population is undergoing apoptosis.Batabulin (T138067) binds covalently and selectively to a subset of the β-tubulin isotypes,thereby disrupting microtubule polymerization. Covalent modification occurs at a conserved Cys-239 shared by the β1,β2,andβ4 tubulin isotypes. Cells exposed to Batabulin become altered in shape, indicating a collapse of the cytoskeleton, and show an increase in chromosomal ploidy. Cell Cycle Analysis |
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Cell Line: |
MCF7 cells |
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Concentration: |
30nM,100nM and 300nM |
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Incubation Time: |
24 hours |
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Result: |
Showed an arrest at the G2/M cell-cycle boundary. |
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Apoptosis Analysis |
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Cell Line: |
MCF7 cells |
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Concentration: |
30nM,100nM and 300nM |
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Incubation Time: |
24 hours or 48 hours |
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Result: |
25-30% of cells showed the reduced DNA content characteristic of apoptotic cells. |
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体内研究 |
Batabulin (T138067; 40mg/kg; intraperitoneal injection; once per week; on days 5,12, and 19;male athymic nude mice) treatment impairs the growth of the drug-sensitive CCRF-CEM tumors. |
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Animal Model: |
Male athymic nude mice (nu/nu) (6-8 week-old, 20-25g) injected withCCRF-CEM cells |
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Dosage: |
40mg/kg |
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Administration: |
Intraperitoneal injection; once per week; on days 5,12,and 19 |
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Result: |
Impaired the growth of the drug-sensitive CCRF-CEM tumors. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
