中文名称: BOC-D-FMK
英文名称: BOC-D-FMK
CAS No: 634911-80-1
分子式: C11H18FNO5
分子量: 263.26
B10734 BOC-D-FMK ≥95% (psaitong)
包装规格:
1mg 5mg 10mg 50mg in glass bottle
溶解性:
溶于DMSO(100 mg/mL 超声)
产品描述:

基本信息

产品编号:B10734

产品名称:BOC-D-FMK

CAS:

634911-80-1

 

储存条件

粉末

-20℃

四年

 

 

分子式:

C11H18FNO5

溶于液体

-80℃

六个月

分子量

263.26

-20℃

一个月

化学名: 

 

 

Solubility (25°C)

 

体外

DMSO

 

Ethanol

 

Water

 

体内(现配现用)

 

 

1mg/ml表示微溶或不溶。

普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。

 

制备储备液

 

浓度

 

溶液体积

质量

 

1mg

 

5mg

 

10mg

1mM

3.7985mL

18.9926mL

37.9853mL

5mM

0.7597mL

3.7985mL

7.5971mL

10mM

0.3799mL

1.8993mL

3.7985mL

 

生物活性

产品描述

是可渗透细胞,不可逆的,泛半胱天冬酶 (caspase) 抑制剂。Boc-D-FMK 抑制 TNF-α 诱导的细胞凋亡的 IC50 值为 39μM。

靶点/IC50

Caspase

 

体外研究

Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFαstimulated reactive oxygen species (ROS) generation.Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39µM. BocD-fmk at 50µM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk.

体内研究

Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsioninduced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle.

 

 

推荐实验方法(仅供参考)

 

动物实验:

 

Rats: Boc-D-FMK is dissolved in DMSO. Male Sprague-Dawley rats group 1 (OBBOC-D) undergo common bile duct ligation and simultaneously treatment with Boc-D-FMK. The first dose of Boc-D-FMK (1.5mg/kg) is injected into the inferior vena cava immediately after bile duct ligation.Subsequent doses of Boc-DFMK (1.5mg/kg twice daily) are given intraperitoneally on the first and second postoperative days. The last dose (1.5mg/kg) is given on the morning of the third postoperative day.

保存条件:
-20℃
UN码:
HazardClass:
危害声明:
安全说明:
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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • =
    *
    *
    *选择对应的单位 *空出希望得到的变量,填写另外两个变量

用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )

  • * = *

连续稀释计算器方程

  • 连续稀释

  • 初始浓度:
  • 稀释倍数:
  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):