中文名称: | BOC-D-FMK | ||||
---|---|---|---|---|---|
英文名称: | BOC-D-FMK | ||||
别名: | 3-[[(叔丁氧基)羰基]氨基]-5-氟-4-氧代戊酸甲酯;3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯 Caspase3-Inhibitor BOC-D-FMK;3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester;Boc-D-FMK;Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester | ||||
CAS No: | 634911-80-1 | 分子式: | C11H18FNO5 | 分子量: | 263.26 |
CAS No: | 634911-80-1 | ||||
分子式: | C11H18FNO5 | ||||
分子量: | 263.26 |
基本信息
产品编号:B10734 |
|||||
产品名称:BOC-D-FMK |
|||||
CAS: |
634911-80-1 |
储存条件 |
粉末 |
-20℃ |
四年 |
|
|
||||
分子式: |
溶于液体 |
-80℃ |
六个月 |
||
分子量 |
263.26 |
-20℃ |
一个月 |
||
化学名: |
|
||||
Solubility (25°C) |
体外 |
DMSO |
|
||
Ethanol |
|
||||
Water |
|
||||
体内(现配现用) |
|
|
|||
<1mg/ml表示微溶或不溶。 |
|||||
普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
|||||
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.7985mL |
18.9926mL |
37.9853mL |
5mM |
0.7597mL |
3.7985mL |
7.5971mL |
10mM |
0.3799mL |
1.8993mL |
3.7985mL |
生物活性
产品描述 |
是可渗透细胞,不可逆的,泛半胱天冬酶 (caspase) 抑制剂。Boc-D-FMK 抑制 TNF-α 诱导的细胞凋亡的 IC50 值为 39μM。 |
靶点/IC50 |
Caspase |
体外研究 |
Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFαstimulated reactive oxygen species (ROS) generation.Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39µM. BocD-fmk at 50µM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk. |
体内研究 |
Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsioninduced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle. |
推荐实验方法(仅供参考)
动物实验: |
|
Rats: Boc-D-FMK is dissolved in DMSO. Male Sprague-Dawley rats group 1 (OBBOC-D) undergo common bile duct ligation and simultaneously treatment with Boc-D-FMK. The first dose of Boc-D-FMK (1.5mg/kg) is injected into the inferior vena cava immediately after bile duct ligation.Subsequent doses of Boc-DFMK (1.5mg/kg twice daily) are given intraperitoneally on the first and second postoperative days. The last dose (1.5mg/kg) is given on the morning of the third postoperative day. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )