| 中文名称: | bpV(phen) | ||||
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| 英文名称: | bpV(phen) | ||||
| 别名: | Potassium bisperoxo(1,10-phenanthroline)oxovanadate (V) hydrate | ||||
| CAS No: | 42494-73-5 | 分子式: | KVO5C12H8N2.XH2O | 分子量: | 350.24(anhydrous basis) |
| CAS No: | 42494-73-5 | ||||
| 分子式: | KVO5C12H8N2.XH2O | ||||
| 分子量: | 350.24(anhydrous basis) | ||||
基本信息
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产品编号： |
B10634 |
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产品名称： |
bpV(phen) |
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CAS: |
42494-73-5 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
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分子量 |
350.24 |
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化学名： |
Potassium bisperoxo(1,10-phenanthroline)oxovanadate (V) hydrate |
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生物活性
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产品描述 |
一种胰岛素模拟物，是一种有效的蛋白酪氨酸磷酸酶(PTP)和PTEN抑制剂，对PTEN，PTP-β和PTP-1B的IC50为38nM，343nM和920nM。bpV(phen)在体外抑制原生动物寄生虫利什曼原虫的增殖 |
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靶点 |
IC50: 38nM (PTEN), 343nM (PTP-β) and 920nM (PTP-1B) Parasite Leishmania Apoptosis |
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体外研究 |
bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells. bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment increases the apoptosis of H/R-injured H9c2 cells. bpV(phen) (5μM; 24.5 hours; H9c2 cells) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C in H/R-injured H9c2 cells. After stimulation of bpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited. bpV(phen) is an insulin-mimetic agent following insulin-receptor tyrosine kinase hyperphosphorylation and activation Cell Viability Assay |
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Cell Line: |
Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
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Concentration: |
5μM |
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Incubation Time: |
24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
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Result: |
Caused a further decrease of cell viability. |
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Apoptosis Analysis |
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Cell Line: |
Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
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Concentration: |
5μM |
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Incubation Time: |
24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
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Result: |
Increased the apoptosis of H/R-injured H9c2 cells. |
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Western Blot Analysis |
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Cell Line: |
Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
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Concentration: |
5μM |
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Incubation Time: |
24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
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Result: |
Showed an increased release of Cytochrome C. |
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体内研究 |
bpV(phen) (5mg/kg; intraperitoneal injection; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume |
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Animal Model: |
Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells |
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Dosage: |
5mg/kg |
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Administration: |
Intraperitoneal injection; daily; for 38 days |
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Result: |
Caused a significant reduction in average tumor volume. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
