中文名称: | BVT 2733 | ||||
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英文名称: | BVT 2733 | ||||
别名: | BVT 2733 BVT2733;3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide | ||||
CAS No: | 376640-41-4 | 分子式: | C17H21ClN4O3S2 | 分子量: | 428.95 |
CAS No: | 376640-41-4 | ||||
分子式: | C17H21ClN4O3S2 | ||||
分子量: | 428.95 |
基本信息
产品编号: |
B10210 |
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产品名称: |
BVT 2733 |
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CAS: |
376640-41-4 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
两年 |
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分子量 |
428.95 |
-20℃ |
一个月 |
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化学名: |
3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide |
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Solubility (25°C): |
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体外:
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DMSO |
86mg/mL (200.48mM) |
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Ethanol |
3mg/mL (6.99mM) |
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Water |
˂1mg/mL |
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体内(现配现用): |
1.请依序添加每种溶剂:10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: ≥ 2.5mg/mL (5.83mM); Clear solution |
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此⽅案可获得 ≥ 2.5mg/mL (5.83mM,饱和度未知) 的澄清溶液。 以 1mL ⼯作液为例,取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中,混合均匀;向上述体系中加⼊ 50μL Tween-80,混合均匀;然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。 |
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2.请依序添加每种溶剂:10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5mg/mL (5.83mM); Clear solution |
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此⽅案可获得 ≥ 2.5mg/mL (5.83mM,饱和度未知) 的澄清溶液。以 1mL ⼯作液为例,取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中,混合均匀。 |
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3.请依序添加每种溶剂:10% DMSO→90% corn oil Solubility: ≥ 2.5mg/mL (5.83mM); Clear solution |
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此⽅案可获得 ≥ 2.5mg/mL (5.83mM,饱和度未知) 的澄清溶液,此⽅案不适⽤于实验周期在半个⽉以上的实验。 以 1mL ⼯作液为例,取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL ⽟⽶油中,混合均匀。 |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.3312mL |
11.6561mL |
23.3122mL |
5mM |
0.4662mL |
2.3312mL |
4.6624mL |
10mM |
0.2331mL |
1.1656mL |
2.3312mL |
50mM |
0.0466mL |
0.2331mL |
0.4662mL |
生物活性
产品描述 |
一种选择性的11β-HSD1(11β-羟基类固醇脱氢酶1型)抑制剂。 |
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靶点 |
11β-HSD1 |
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体外研究 |
BVT 2733 (100μM; 24 hours) co-treatment with PA (100μM) reduces MCP-1 expression in fully differentiation adipocytes. BVT 2733 (50-100μM; 24 hours) reduces the inflammation protein levels (MCP-1, IL-6) in medium in J774.1 macrophages by Elisa. RT-PCR |
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Cell Line: |
Differentiation adipocytes |
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Concentration: |
100μM |
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Incubation Time: |
24 hours |
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Result: |
Down-regulated MCP-1 mRNA level. |
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体内研究 |
BVT-2733 (oral administration; 100mg/kg; twice daily; 2 weeks) attenuates the arthritis severity and anti-CII level and decreases the levels of serum TNF-α, IL-1β, IL-6 and IL-17 in CIA mice. BVT 2733 (oral administration; 100mg/kg; dosed (09.00 and 17.00 h); last 4 weeks) exhibits decreased body weight and enhanced glucose tolerance and insulin sensitivity when it compares to control mice. It also down-regulated the expression of inflammation-related genes including monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α) and the number of infiltrated macrophages within the adipose tissue in vivo |
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Animal Model: |
Collagen-induced arthritis (CIA) mice |
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Dosage: |
100mg/kg |
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Administration: |
Oral administration; twice daily; 2 weeks |
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Result: |
Reduced synovial inflammation and joint destruction. |
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Animal Model: |
C57BL/6J mice |
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Dosage: |
100mg/kg |
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Administration: |
Oral administration; dosed (09.00 and 17.00 h); last 4 weeks |
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Result: |
Improved metabolic homeostasis and suppressed the inflammation of adipose tissue in diet-induced obese mice. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )