黄芩素 - CAS:491-67-8 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	黄芩素促销
英文名称:	Baicalein
别名:	三羟黄酮 Baicalein
CAS No:	491-67-8	分子式:	C₁₅H₁₀O₅	分子量:	270.24
CAS No:	491-67-8
分子式:	C₁₅H₁₀O₅
分子量:	270.24
MDL:	MFCD00017459	EINEC:	661431
EINEC:	661431

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B10126 黄芩素 ≥98%(HPLC),分析标准品 (psaitong)

相关产品

包装规格：

20mg in glass bottle

产品描述：

基本信息

产品编号：	B10126
产品名称：	Baicalein
CAS:	491-67-8	储存条件	粉末	室温	四年

分子式：	C15H10O5		溶于液体	-80℃	两年
分子量	270.24			-20℃	一个月
化学名：	5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
Solubility (25°C)：
体外:	DMSO	54mg/mL (199.82mM)
	Ethanol	1mg/mL (3.7mM)
	Water	Insoluble
体内(现配现用):	1.请依序添加每种溶剂：0.5% CMC-Na/saline water Solubility: 20mg/mL (74.01mM); Suspended solution; Need ultrasonic
	2.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: 2.5mg/mL (9.25mM); Clear solution; Need ultrasonic
	此⽅案可获得 2.5mg/mL (9.25mM) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50μL Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。
	3.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: 2.5mg/mL (9.25mM); Clear solution; Need ultrasonic
	此⽅案可获得 2.5mg/mL (9.25mM) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	3.7004mL	18.5021mL	37.0041mL
5mM	0.7401mL	3.7004mL	7.4008mL
10mM	0.3700mL	1.8502mL	3.7004mL
50mM	0.0740mL	0.3700mL	0.7401mL

生物活性

产品描述	Baicalein是CYP2C9和脯氨酰肽链内切酶抑制剂。
靶点	CYP2C9
体外研究	Baicalein suppresses mitogen induced T cell proliferation and cytokine secretion in vitro. Pre-treatment with baicalein significantly suppresses Con A or anti-CD3/CD28 mAb induced proliferation as well as cytokine secretion at 25μM. Baicalein treatment induces DNA binding of NF-κB but inhibits thioredoxin activity in the nuclear compartment. Baicalein suppresses proliferation, migration, and invasion of MDA-MB-231 cells in a time- and dose-dependent manner. Baicalein significantly decreases the expression of SATB1 in MDA-MB-231 cells. Baicalein also downregulates the expression of Wnt1 and β-catenin proteins and transcription level of Wnt/β-catenin-targeted genes
体内研究	Baicalein suppresses induction of graft versus host disease but does not inhibit homeostatic proliferation of T-cells in mice. This observation clearly shows potent anti-inflammatory activity of baicalein in vivo. Rats treated with baicalein are protected against an increase in heart to body weight ratio, plasma level of brain natriuretic peptides, intraventricular septum thickness, myocardial collagen volume of left ventricle (all P<0.05, respectively). The antifibrotic effects of baicalein are further illustrated by the suppressed expression of left ventricle pro-collagens I and III accompanied by the decreased expression of 12-lipoxygenase, and by reduced expression and activity of matrix metallopeptidase 9 and extracellular signalregulated kinases. Baicalein can inhibit cardiac fibrosis in hypertensive rats

推荐实验方法(仅供参考)

Cell Assay

MTT assay is conducted to evaluate the effect of baicalein on proliferation of breast cancer cells. MDA-MB-231 cells are routinely digested, collected, and then seeded in 96-well plates at a density of 8×10³ cells/well. After incubation for 12-24 hours, cells are treated with 0, 20, 40, 60, 80, 100, and 120μM baicalein according to their experimental grouping and then incubated at 37°C for 24, 48, and 72 hours

Animal Administration

Rats: Baicalein is suspended in 1% methylcellulose. Rats are treated with baicalein suspension via oral garvage. SHR and WKY rats are divided into 4 groups (n=8 per group): 12-week treatment with high-dose (200mg/kg/day) or low-dose (50mg/kg/day) group; and 4-week treatment with high-dose or low-dose group. The 12-week and 4-week negative control groups of SHR and WKY rats (n=8 per group) receive vehicle while positive control groups (Val group, n=8 per group) receive valsartan (20mg/kg/day) for comparison.

Mice: To study the in vivo anti-inflammatory efficacy of baicalein, graft-versus-host disease (GVHD) model is used. Splenic lymphocytes from C57BL/6 mice are incubated with baicalein in vitro (25μM, 4h) and adoptively transferred to immunecompromised Balb/c mice

保存条件：

室温

UN码：

HazardClass：

危害声明：

安全说明：

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参考文献 & 客户发表文献

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

质量 =

浓度 *

体积 *

分子量

*选择对应的单位 *空出希望得到的变量，填写另外两个变量

用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入输出 )

* = *

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

摩尔浓度计算公式

稀释公式

连续稀释计算器方程

连续稀释

计算结果