中文名称: | AZD7507 | ||||
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英文名称: | AZD7507 | ||||
别名: | AZD7507 4-(2-Fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide | ||||
CAS No: | 1041852-85-0 | 分子式: | C23H27FN6O3 | 分子量: | 454.5064 |
CAS No: | 1041852-85-0 | ||||
分子式: | C23H27FN6O3 | ||||
分子量: | 454.5064 |
基本信息
产品编号:A70393 |
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产品名称:AZD7507 |
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CAS: |
1041852-85-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式: |
溶于液体 |
-80℃ |
六个月 |
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分子量 |
454.51 |
-20℃ |
一个月 |
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化学名: |
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Solubility (25°C) |
体外 |
DMSO |
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Ethanol |
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Water |
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体内(现配现用) |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
2.2002mL |
11.0011mL |
22.0022mL |
5mM |
0.4400mL |
2.2002mL |
4.4004mL |
10mM |
0.2200mL |
1.1001mL |
2.2002mL |
生物活性
产品描述 |
一种有效的、可口服的 CSF-1R 抑制剂,具有抗肿瘤活性。 |
靶点/IC50 |
CSF-1R |
体外研究 |
AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC50,32nM), shows inhibitory activity against hERG and NaV1.5, with IC50s of >30 and 26μM. |
体内研究 |
AZD7507 has good rat oral PK, with in vivo clearance of 7mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC50 is >20μM. AZD7507 significantly decreases the number of CD68+macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells. |
推荐实验方法(仅供参考)
动物实验: |
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Mice Male CD1 nude mice are injected subcutaneously with 5 × 105 human ICC cells from human cell line WITT-1, CC-LP-1, or SNU1079 (n = 24 in all cases) suspended in culture media/RGF Matrigel (Gibco) mix (1:1). Cells are engrafted bilaterally in the flank and allowed to form tumors over 3 weeks. Once palpable tumors have formed, mice are randomized into 3 groups using GraphPad online software. Xenografted mice are injected with liposomal clodronate at 4 μL/g intravenously. The control for this treatment is saline alone or liposomes not containing clodronate (both given at 4 μL/g intravenously). All of these treatments are given every 48 hours for 3 weeks. CSFR1 inhibitors AZD7507 and GW2580 are made up in sterile water containing 0.5% methylcellulose and 0.1% Tween-80. AZD7507 is given twice daily at 100 mg/kg, whereas GW2580 is given daily at 160 mg/kg. Control animals are given water containing 0.5% methylcellulose and 0.1% Tween-80. ICG-001 (5 mg/kg)or C-59 (20 mg/kg) is given by intraperitoneal injection. The vehicle for this is physiological saline. Control animals are given vehicle alone. In all cases inhibitors and vehicle are given 3 times per week. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )