| 中文名称: | 扁桃苷 | ||||
|---|---|---|---|---|---|
| 英文名称: | Amygdalin | ||||
| 别名: | D-扁桃腈-β-龙胆二糖苷, D-扁桃腈6-O-β-D-葡糖基-β-D-葡萄糖苷 Amygdalin | ||||
| CAS No: | 29883-15-6 | 分子式: | C20H27NO11 | 分子量: | 457.43 |
| CAS No: | 29883-15-6 | ||||
| 分子式: | C20H27NO11 | ||||
| 分子量: | 457.43 | ||||
| MDL: | MFCD00006598 | EINEC: | 249-925-3 | ||
| EINEC: | 249-925-3 | ||||
基本信息
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产品编号： |
A70094 |
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产品名称： |
Amygdalin |
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CAS: |
29883-15-6 |
储存条件 |
粉末 |
室温 |
四年 |
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分子式： |
溶于液体 |
-80℃ |
两年 |
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分子量 |
457.43 |
-20℃ |
一个月 |
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化学名： |
(2R)-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy](phenyl)acetonitrile |
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Solubility (25°C)： |
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体外:
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DMSO |
91mg/mL (198.93mM) |
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Ethanol |
Insoluble |
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Water |
Insoluble |
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体内(现配现用): |
1.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5mg/mL (5.47mM); Clear solution |
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此⽅案可获得 ≥ 2.5mg/mL (5.47mM，饱和度未知) 的澄清溶液。 以 1 mL ⼯作液为例，取 100μL 25.0mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。 |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.1861 mL |
10.9306 mL |
21.8613 mL |
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5mM |
0.4372 mL |
2.1861 mL |
4.3723 mL |
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10mM |
0.2186 mL |
1.0931 mL |
2.1861 mL |
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50mM |
0.0437 mL |
0.2186 mL |
0.4372 mL |
生物活性
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产品描述 |
一种含氰化物的糖苷，可用作底物来鉴定、鉴别和表征麦芽糖酶、乳清酶和β-葡萄糖苷酶等酶。 |
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体外研究 |
Amygdalin has antitumor activity. Some advances had been made on the antitumor mechanism of amygdalin. Amygdalin downregulates especially genes belonging to cell cycle category: exonuclease 1, ATP-binding cassette, sub-family F, member 2, MRE11 meiotic recombination 11 homolog A, topoisomerase (DNA) I, and FK506 binding protein 12-rapamycin-associated protein 1. RT-PCR analysis reveals that mRNA levels of these genes are also decreased by amygdalin treatment in SNU-C4 human colon cancer cells |
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体内研究 |
Amygdalin is effective at alleviating inflammatory pain and that it can be used as an analgesic with anti-nociceptive and antiinflammatory activities. The intramuscular injection of amygdalin significantly reduced the formalin-induced tonic pain in both early (the initial 10 min after formalin injection) and late phases (10-30 min following the initial formalin injection). During the late phase, amygdalin reduces the formalin-induced pain in a dose-dependentmanner in a dose range less than 1mg/kg |
推荐实验方法(仅供参考)
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Cell Assay |
Cell viability is determined by MTT assay. Cells are seeded in triplicate at a concentration of 1×105 cells/well on a 96-well plate. SNU-C4 cells are treated with amygdalin at concentrations of 0.25, 0.5, 2.5, and 5mg/mL for 24 h. After MTT is added to each group, the cells are incubated for 4 h. Then, they are further incubated for 1 h, including the solution in which MTT is dissolved |
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Animal Administration |
Rats: The amygdalin powder is dissolved in saline and diluted with appropriate medium. Male Sprague–Dawley rats weighing 230-250 g are used for this experiment. 50mL of 5% formalin are injected to produce fomalin-induced pain in the rats. Thirty minutes before the formalin injection to induce pain, the rats are given an intramuscular injection of amygdalin solution (0.1, 0.5, 1.0, 10mg/kg), or saline as a vehicle control |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
