基本信息
产品编号: |
A20053 |
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产品名称: |
Atropine |
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CAS: |
51-55-8 |
储存条件 |
粉末 |
2-8℃ |
四年 |
分子式: |
溶于液体 |
-80℃ |
6个月 |
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分子量: |
289.37 |
-20℃ |
1个月 |
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化学名: |
(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate |
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Solubility (25°C): |
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体外:
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DMSO |
58mg/mL (200.43mM) |
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Ethanol |
58mg/mL (200.43mM) |
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Water |
Insoluble |
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体内(现配现用): |
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<1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得,实际溶液度可能与公布值有所偏差,属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;⼀旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
制备储备液
浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
1mM |
3.4558mL |
17.2789mL |
34.5578mL |
5mM |
0.6912mL |
3.4558mL |
6.9116mL |
10mM |
0.3456mL |
1.7279mL |
3.4558mL |
50mM |
0.0691mL |
0.3456mL |
0.6912mL |
生物活性
产品描述 |
竞争性的毒蕈碱乙酰胆碱受体(mAChR)拮抗剂,有抗近视效果。Atropine 阻断乙酰胆碱对心率和收缩力的抑制作用,可能也会导致心动过速。 |
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靶点 |
Human Endogenous Metabolite |
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体外研究 |
Atropine increases cAMP independently of M1/2/3-muscarinic receptors in cardiomyocytes.Atropine inhibits the cAMP-specific phosphodiesterase PDE4 in cardiomyocytes.Atropine might inhibit myopia viaα2A-adrenoceptors,instead of through the mAChR M4/cM4 receptor subtype. |
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体内研究 |
Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4 (PDE4).Atropine (30-60mg/kg/day;s.c.) causes changes in mouse motility that is not correlates to its modification of ACh levels in the CNS. |
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Animal Model: |
Female albino Swiss Morini mice (20-25g) |
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Dosage: |
30mg/kg,40mg/kg,60mg/kg |
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Administration: |
Subcutaneous injection;daily |
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Result: |
Chronic administration of atropine caused significant increase of motility at doses which caused no modification of ACh levels. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液,使用的计算公式为:
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为:C1V1 = C2V2 ( 输入 输出 )