| 中文名称: | Adelmidrol | ||||
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| 英文名称: | Adelmidrol | ||||
| 别名: | N1,N9-双(2-羟乙基)壬二酰胺；阿地米屈 N,N'-bis(2-hydroxyethyl)nonanediamide | ||||
| CAS No: | 1675-66-7 | 分子式: | C13H26N2O4 | 分子量: | 274.36 |
| CAS No: | 1675-66-7 | ||||
| 分子式: | C13H26N2O4 | ||||
| 分子量: | 274.36 | ||||
基本信息
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产品编号： |
A12798 |
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产品名称： |
Adelmidrol |
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CAS: |
1675-66-7 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
274.36 |
-20℃ |
1个月 |
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化学名： |
N,N'-bis(2-hydroxyethyl)nonanediamide |
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Solubility (25°C)： |
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体外:
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DMSO |
55mg/mL (200.46mM) |
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Ethanol |
28mg/mL (102.05mM) |
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Water |
55mg/mL (200.46mM) |
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体内(现配现用): |
请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照In Vitro⽅式配制澄清的储备液，再依次添加助溶剂：为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐是指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶 1.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility:≥2.08mg/mL(7.58mM);Clear solution 2.请依序添加每种溶剂：10% DMSO→90%(20% SBE-β-CD in saline) Solubility:≥2.08mg/mL(7.58mM);Clear solution 3.请依序添加每种溶剂：10% DMSO→90% corn oil Solubility:≥2.08mg/mL(7.58mM);Clear solution |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
3.6448mL |
18.2242mL |
36.4485mL |
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5mM |
0.7290mL |
3.6448mL |
7.2897mL |
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10mM |
0.3645mL |
1.8224mL |
3.6448mL |
生物活性
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产品描述 |
Adelmidrol发挥重要的抗炎作用，部分依赖于PPARγ。Adelmidrol降低NF-κB易位，和COX-2表达。 |
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靶点 |
NF-κB |
COX-2 |
PPARγ |
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体外研究 |
Adelmidrol is a palmitoylethanolamide analogue. Adelmidrol reduces NF-κB translocation,COX-2,and p-ERK expression;proinflammatory cytokine release;and the incidence of nitrotyrosine and poly(ADP)ribose in the colon. |
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体内研究 |
Adelmidrol (10mg/kg,o.s.) reduces significantly the degree and severity of the macroscopic and histologic signs of colon injury.Moreover,4 days after colitis induced by dinitrobenzene sulfonic acid (DNBS) treatment,all mice have diarrhea and a reduction in body weight (compared with the sham groups).Adelmidrol (10mg/kg,o.s.) treatment significantly reduces the loss of body weight.The inflammatory bowel disease (IBD) induced by DNBS intrarectally administered is also characterized by an augmentation in myeloperoxidase (MPO) activity,an indicator of neutrophil accumulating in the colon.This is consistent with light microscopic observations showing the colon of vehicle-treated DNBS mice to contain a large number of neutrophils.In contrast,Adelmidrol (10mg/kg,o.s.) significantly reduces the degree of polymorphonuclear cell infiltration (determined as reduction in MPO activity) in inflamed colon. |
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推荐实验方法(仅供参考)
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动物实验: |
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Mice Male adult CD1 mice (25-30g) and male mice (20-27g) are placed in a controlled environment and maintained on a 12-hour light/dark cycle with food and water available ad libitum.Mice are casually divided into the following groups (10 in each group) (1)Sham+vehicle group:Vehicle solution (saline) is given by oral administration for 4 days.(2) Sham+Adelmidrol (10mg/kg):Administered o.s.for 4 days.(3) DNBS+vehicle:Mice are injected by DNBS as described,and vehicle (saline) is given o.s.each day for 4 days,starting 60 minutes after the injection of DNBS.(4) DNBS+Adelmidrol (10mg/kg):Mice are injected by DNBS as described,and Adelmidrol (10mg/kg) is given o.s.each day,starting 60 minutes after administration of DNBS. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
