| 中文名称: | ADX71743 | ||||
|---|---|---|---|---|---|
| 英文名称: | ADX71743 | ||||
| 别名: | 6-(2,4-Dimethylphenyl)-2-ethyl-4,5,6,7-tetrahydro-1,3-benzoxazol-4-one | ||||
| CAS No: | 1431641-29-0 | 分子式: | C17H19NO2 | 分子量: | 269.34 |
| CAS No: | 1431641-29-0 | ||||
| 分子式: | C17H19NO2 | ||||
| 分子量: | 269.34 | ||||
基本信息
|
产品编号： |
A12773 |
||||
|
产品名称： |
ADX71743 |
||||
|
CAS: |
1431641-29-0 |
储存条件 |
粉末 |
-20℃ |
三年 |
|
分子式： |
溶于液体 |
-80℃ |
二年 |
||
|
分子量： |
269.34 |
|
|
||
|
化学名： |
6-(2,4-Dimethylphenyl)-2-ethyl-4,5,6,7-tetrahydro-1,3-benzoxazol-4-one |
||||
|
Solubility (25°C)： |
|||||
|
体外:
|
DMSO |
|
|||
|
Ethanol |
|
||||
|
Water |
|
||||
|
体内(现配现用): |
|
||||
|
＜1mg/ml表示微溶或不溶。 |
|||||
|
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
|||||
|
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
|||||
生物活性
|
产品描述 |
一种高度选择性，非竞争性且透过血脑屏障的代谢型谷氨酸受体7负变构调节剂(mGlu7 NAM)。ADX71743具有抗焦虑活性。 |
|
|
靶点 |
mGlu7 |
|
|
体外研究 |
ADX71743 has an IC50 of 300nM in-house cell lines.Pretreatment of ADX71743 (3μM;for 20 min) before high-frequency stimulation (HFS) results in an almost complete blockade of LTP induction.ADX71743 (0.1,10μM) reverses L-AP4-induced depression of synaptic transmission and results in a concentration-dependent reversal of the L-AP4-induced depression. 0.1μM ADX71743 reverses the effects of L-AP4 by 11% and 10μM results in a 20% reversal.ADX71743 can against an EC80 of glutamate (IC50 of 22nM) as well as against an EC80 of L-AP4 (IC50 of 125nM). |
|
|
体内研究 |
ADX71743 (50,100,150mg/kg;SC) results in robust reductions in numbers of buried marbles to near maximal levels at lower doses (50 and 100mg/kg).ADX71743 (12.5,100mg/kg for mice and 100mg/kg for rat;SC) has a T1/2 of 0.68,0.40 hours,a Cmax of 1380,12766ng/ml of 12.5mg/kg and 100mg/kg in mice. |
|
|
Animal Model: |
Adult male C57Bl6/J mice (24-30g) |
|
|
Dosage: |
50,100,150mg/kg |
|
|
Administration: |
SC |
|
|
Result: |
Resulted in robust reductions in numbers of buried marbles to near maximal levels at lower doses (50 and 100mg/kg). |
|
|
|
||
|
Animal Model: |
Adult male C57Bl6/J mice (24-30g) and Sprague-Dawley rats (250-350g) |
|
|
Dosage: |
12.5,100mg/kg for mice and 100mg/kg for rat (Pharmacokinetic Analysis) |
|
|
Administration: |
SC |
|
|
Result: |
Had a T1/2 of 0.68,0.40 hours,a Cmax of 1380,12766ng/ml of 12.5mg/kg and 100mg/kg in mice.Had a T1/2 of 1.5 hours,a Cmax of 16800ng/ml of 100mg/kg in rat. |
|
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
