| 中文名称: | Adriforant hydrochloride | ||||
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| 英文名称: | Adriforant hydrochloride | ||||
| 别名: | PF-3893787 hydrochloride | ||||
| CAS No: | 2096455-90-0 | 分子式: | C13H25Cl3N6 | 分子量: | 371.74 |
| CAS No: | 2096455-90-0 | ||||
| 分子式: | C13H25Cl3N6 | ||||
| 分子量: | 371.74 | ||||
基本信息
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产品编号： |
A11608 |
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产品名称： |
Adriforant hydrochloride |
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CAS: |
2096455-90-0 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
371.74 |
-20℃ |
1个月 |
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化学名： |
PF-3893787 hydrochloride |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.6901mL |
13.4503mL |
26.9005mL |
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5mM |
0.5380mL |
2.6901mL |
5.3801mL |
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10mM |
0.2690mL |
1.3450mL |
2.6901mL |
生物活性
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产品描述 |
一种新型组胺H4受体亲和型拮抗剂(Ki=2.4nM)，也是一种H4受体功能性拮抗剂(Ki=1.56 nM)。 |
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靶点 |
Ki:2.4nM (H4R bind),1.56nM (H4R func) |
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体外研究 |
Adriforant is tested and observed binding Ki=2.4nM and functional Ki=1.56nM for H4R.Data from functional assays produce convergent projections of the free plasma efficacious concentration and Adriforant (Compound 13) is fast on/fast off on rhH4R.The in vitro IC50 on human native isolated eosinophils assessing actin polymerisation is 1.16nM and assuming need 10 times the IC50 for >90% receptor occupancy (and therefore near complete inhibition of the response) suggested a concentration of 12nM.The data in the whole blood GAFS assay demonstrates that the imetit induced shape change is completely blocked at a total blood concentration of 30nM (which correcting for PPB and blood partitioning equates to approximately 10nM free).For the purpose of dose projection and safety margin calculation, a Ceff/Cmin concentration of 10-15nM is used. |
本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
