| 中文名称: | Amibegron hydrochloride | ||||
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| 英文名称: | Amibegron hydrochloride | ||||
| 别名: | Amibegron盐酸盐标准品 SR 58611A | ||||
| CAS No: | 121524-09-2 | 分子式: | C22H26ClNO4.HCl | 分子量: | 440.36 |
| CAS No: | 121524-09-2 | ||||
| 分子式: | C22H26ClNO4.HCl | ||||
| 分子量: | 440.36 | ||||
基本信息
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产品编号： |
A11434 |
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产品名称： |
Amibegron hydrochloride |
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CAS: |
121524-09-2 |
储存条件 |
粉末 |
-20℃ |
四年 |
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分子式： |
溶于液体 |
-80℃ |
6个月 |
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分子量： |
440.36 |
-20℃ |
1个月 |
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化学名： |
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Solubility (25°C)： |
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体外:
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DMSO |
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Ethanol |
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Water |
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体内(现配现用): |
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＜1mg/ml表示微溶或不溶。 |
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普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。 |
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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制备储备液
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浓度
溶液体积 质量 |
1mg |
5mg |
10mg |
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1mM |
2.2709mL |
11.3543mL |
22.7087mL |
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5mM |
0.4542mL |
2.2709mL |
4.5417mL |
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10mM |
0.2271mL |
1.1354mL |
2.2709mL |
生物活性
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产品描述 |
一种选择性的β3-adrenoceptor激动剂，对大鼠结肠β-adrenoceptor的 EC50值为3.5nM;Amibegron hydrochloride具有抗焦虑和抗抑郁的活性。 |
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靶点 |
EC50:3.5nM (β-adrenoceptor,from rat colon),499nM (β-adrenoceptor,from rat uterus),1.2μM (β2-adrenoceptor,from cerebellum),4.6μM (β1-adrenoceptor1,from cortex) |
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体外研究 |
Amibegron hydrochloride (SR 58611A) is a selective β-adrenoceptor agonist,with an EC50 of 3.5nM for β-adrenoceptor in rat colon,and 499nM in rat uterus.Amibegron hydrochloride (SR 58611A) shows little effect on β1-and β2-adrenoceptors,5-HT uptake, noradrenaline (NA) uptake,and dopamine (DA) uptake from rat brain tissue,with IC50s of 4.6 and 1.2,0.58,2.5 and 3.2μM,respectively;exhibits no effect on 5-HT1A,5-HT2,MAO-A and MAO-B (IC50>10μM). |
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体内研究 |
Amibegron hydrochloride (SR 58611A,0.1 to 0.3mg/kg,i.p.) potentiates the toxicity produced by yohimbine in mice.Amibegron hydrochloride (0.6 and 2mg/kg,i.p.) is also active in the learned helplessness model of antidepressant-like activity in rats.However,Amibegron hydrochloride exhibits no effect on the spontaneous locomotor activity of mice at up to 10mg/kg and of rats at up tp 30mg/kg.Amibegron hydrochloride (3 and 10mg/kg,p.o.) increases the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas such as cortex,hippocampus,hypothalamus,striatum.In addition,Amibegron hydrochloride (10mg/kg,p.o.) promotes the release of 5-HT in rat prefrontal cortex.Systemic (3mg/kg,i.v.) or chronic administration of SR58611A (10mg/kg,p.o.) does not affect the activity of serotonergic neurons in the rat dorsal raphe nucleus. |
推荐实验方法(仅供参考)
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动物实验: |
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Mice This test is performed on groups of 10-20 mice.Amibegron hydrochloride (0.1 to 0.3mg/kg) or vehicle are administered i.p.30 min before the administration of yohimbine.Yohimbine hydrochloride is administered s.c.at a dose of 30mg/kg always at the same time of day,between 1.30 and 3.30 p.m.Lethality is recorded the next morning at 9 a.m. Rats The rats (n=10 per group) are treated randomly according to one of the following protocols:the control sample,which receives no shock,is given vehicle; experimental animals with inescapable shock are treated daily with vehicle or Amibegron hydrochloride (up to 30mg/kg).Animals are treated orally over 5 consecutive days,i.e.6h after shock pretreatment on day 1,and then twice per day,a half dose in the morning (30 min before shuttle-box session) and a half dose in the afternoon (except on the 5th day).Statistical analysis is performed on themean number of escape failures using a two-way analysis of variance followed by Dunnett's test. |
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本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为：
质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)
摩尔浓度计算公式
用本工具协助配置特定浓度的溶液，使用的计算公式为：
开始浓度 x 开始体积 = 最终浓度 x 最终体积
稀释公式
稀释公式一般简略地表示为：C1V1 = C2V2 ( 输入 输出 )
