氨茶碱 - CAS:317-34-0 - CAS号查询_生物试剂_化学试剂_分析试剂

中文名称:	氨茶碱
英文名称:	Aminophylline
别名:	胺非林;乙二氨茶碱 Theophylline ethylenediamine;1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)
CAS No:	317-34-0	分子式:	C₁₆H₂₄N₁₀O₄	分子量:	420.43
CAS No:	317-34-0
分子式:	C₁₆H₂₄N₁₀O₄
分子量:	420.43
MDL:	MFCD00013221	EINEC:	206-264-5
EINEC:	206-264-5

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A11424 氨茶碱 ≥98% (psaitong)

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包装规格：

500mg in glass bottle

溶解性：

溶于水（6.25mg/mL 超声），溶于DMSO（14.29mg/mL 超声）

产品描述：

基本信息

产品编号：	A11424
产品名称：	Aminophylline
CAS:	317-34-0	储存条件	粉末	2-8℃	四年

分子式：	C16H24N10O4		溶于液体	-80℃	两年
分子量	420.43			-20℃	一个月
化学名：	1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)
Solubility (25°C)：
体外:	DMSO	53mg/mL (126.06mM)
	Ethanol	1mg/mL (2.37mM)
	Water	81mg/mL (192.65mM)
体内(现配现用):	1.请依序添加每种溶剂：PBS Solubility: 22mg/mL (52.33mM); Clear solution; Need ultrasonic 2.请依序添加每种溶剂：10% DMSO→40% PEG300→5% Tween-80→45% saline Solubility: 1.43mg/mL (3.40mM); Clear solution; Need ultrasonic
	此⽅案可获得 1.43mg/mL (3.40mM) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 14.299999mg/mL 的澄清 DMSO 储备液加到 400μL PEG300 中，混合均匀；向上述体系中加⼊ 50μL Tween-80，混合均匀；然后继续加⼊ 450μL ⽣理盐⽔定容⾄ 1mL。
	3.请依序添加每种溶剂：10% DMSO→90% (20% SBE-β-CD in saline) Solubility: ≥ 1.43mg/mL (3.40mM); Clear solution
	此⽅案可获得 ≥ 1.43mg/mL (3.40mM，饱和度未知) 的澄清溶液。以 1mL ⼯作液为例，取 100μL 14.299999mg/mL 的澄清 DMSO 储备液加到 900μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。
	4.请依序添加每种溶剂：10% DMSO→90% corn oil Solubility: ≥ 1.43mg/mL (3.40mM); Clear solution
	此⽅案可获得 ≥ 1.43mg/mL (3.40mM，饱和度未知) 的澄清溶液，此⽅案不适⽤于实验周期在半个⽉以上的实验。以 1mL ⼯作液为例，取 100μL 14.299999mg/mL 的澄清 DMSO 储备液加到 900μL ⽟⽶油中，混合均匀。
＜1mg/ml表示微溶或不溶。
普西唐提供的所有化合物浓度为内部测试所得，实际溶液度可能与公布值有所偏差，属于正常的批间细微差异现象。
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

制备储备液

浓度溶液体积质量	1mg	5mg	10mg
1mM	2.3785mL	11.8926mL	23.7852mL
5mM	0.4757mL	2.3785mL	4.7570mL
10mM	0.2379mL	1.1893mL	2.3785mL
50mM	0.0476mL	0.2379mL	0.4757mL

生物活性

产品描述

一种竞争性，非选择性的磷酸二酯酶 (PDE) 抑制剂。Aminophylline 是竞争性的腺苷受体 (adenosine receptor) 拮抗剂。Aminophylline 具有肺血管扩张和支气管扩张作用，有用于哮喘研究的潜力。

靶点

adenosine receptor

PDE

0.12mM

体外研究

Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate. Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of airway obstruction from asthma or COPD. It is used off-label as a reversal agent during nuclear stress testing. Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor.Adenosine is an endogenous extracellular messenger that can regulate myocardial oxygen needs. It acts through cellular surface receptors which effect intracellular signalling pathways to increase coronary artery blood flow, slow heart rate, block atrioventricular node conduction, suppress cardiac automaticity, and decrease βadrenergic effects on contractility. Adenosine also antagonizes chronotropic and ionotropic effects of circulating catecholamines. Overall, adenosine decreases the heart's rate and force of contraction, which increases blood supply to the cardiac muscle. Given specific circumstances this mechanism (which is intended to protect the heart) may cause atropineresistant refractory bradyasystole. Adenosine's effects are concentration-dependent. Adenosine's receptors are competitively antagonized by methylxanthines such as aminophylline. Aminophylline competitively antagonizes the cardiac actions of adenosine at the cell surface receptors. Thus, it increases heart rate and contractility.

保存条件：

2-8℃

UN码：

HazardClass：

危害声明：

安全说明：

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